Novel antifungal activity of oligostyrylbenzenes compounds on Candida tropicalis biofilms.

Medical Mycology
Melisa A QuinterosMaría G Paraje

Abstract

As sessile cells of fungal biofilms are at least 500-fold more resistant to antifungal drugs than their planktonic counterparts, there is a requirement for new antifungal agents. Olygostyrylbenzenes (OSBs) are the first generation of poly(phenylene)vinylene dendrimers with a gram-positive antibacterial activity. Thus, this study aimed to investigate the antifungal activity of four OSBs (1, 2, 3, and 4) on planktonic cells and biofilms of Candida tropicalis. The minimum inhibitory concentration (MIC) for the planktonic population and the sessile minimum inhibitory concentrations (SMIC) were determined. Biofilm eradication was studied by crystal violet stain and light microscopy (LM), and confocal laser scanning microscopy (CLSM) was also utilized in conjunction with the image analysis software COMSTAT. Although all the OSBs studied had antifungal activity, the cationic OSBs were more effective than the anionic ones. A significant reduction of biofilms was observed at MIC and supraMIC50 (50 times higher than MIC) for compound 2, and at supraMIC50 with compound 3. Alterations in surface topography and the three-dimensional architecture of the biofilms were evident with LM and CLSM. The LM analysis revealed that the C. tropicalis s...Continue Reading

References

Aug 27, 2002·Emerging Infectious Diseases·Rodney M Donlan
Jul 20, 2006·Journal of Medical Microbiology·Mohammed A Al-Fattani, L Julia Douglas
Jun 27, 2007·Antimicrobial Agents and Chemotherapy·Analy S MeloBeth A Arthington-Skaggs
Feb 6, 2008·FEMS Yeast Research·Fernando César BizerraSueli Fumie Yamada-Ogatta
Apr 24, 2010·Journal of Medical Microbiology·Rajendra J KothavadeM H Panthaki
Dec 8, 2010·FEMS Microbiology Letters·Julio E Arce MirandaMaría G Paraje
Mar 1, 2011·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Céline MessierDaniel Grenier
Mar 18, 2011·Trends in Microbiology·Sónia SilvaJoana Azeredo
May 5, 2011·Medical Mycology·Heather T TaffDavid R Andes
Jan 4, 2012·The American Journal of Medicine·Michael A Pfaller
Apr 21, 2012·International Journal of Microbiology·Gordon RamageCraig Williams
Nov 20, 2013·Chemistry : a European Journal·Ramiz A BoulosScott G Stewart
Oct 3, 2014·Cold Spring Harbor Perspectives in Medicine·Jigar V DesaiDavid R Andes
Feb 11, 2015·International Journal of Molecular Sciences·Yan XueYi Zhang
Sep 27, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Mariana Andrea PeraltaMaría Gabriela Paraje
Mar 11, 2016·Pathogens and Disease·Christina TsuiMary Ann Jabra-Rizk
Oct 22, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Juliana MarioniMaría Gabriela Paraje
Oct 23, 2016·Journal of Applied Microbiology·K HirotaY Miyake
Nov 23, 2016·Journal of Dental Research·B Bechinger, S-U Gorr
May 10, 2017·ACS Applied Materials & Interfaces·Pengbo ZhangShu Wang
Nov 15, 2017·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Rafael Gomes Von BorowskiSimone Cristina Baggio Gnoatto
Jan 27, 2018·Journal of Fungi·Johannes Wagener, Veronika Loiko
Feb 25, 2018·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mariana Andrea PeraltaMaría Gabriela Paraje
Sep 19, 2018·Microbial Pathogenesis·Francieli Capote-BonatoTerezinha Inez Estivalet Svidzinski
Dec 12, 2018·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·W LopesA Schrank
Feb 17, 2019·The Journal of Chemical Physics·Mónica MoralAmparo Navarro
Nov 5, 2019·Frontiers in Microbiology·Karen G N OshiroOctávio Luiz Franco

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