Novel antigen delivery technologies: a review

Drug Delivery and Translational Research
Deepika JainRanjit Singh

Abstract

Over the past few years, new insights into immunobiology and delivery systems have allowed the development of better vaccines and for a wider range of diseases. Currently available vaccines represent outstanding success story in modern medicine and have had a dramatic effect on morbidity and mortality worldwide. Conventional vaccines have been based on live attenuated, or killed, viruses or bacteria, or recombinant proteins from these organisms. The design of live attenuated vaccines depended to some extent on serendipity and resulted in low success rates. Both live attenuated and killed vaccines require handling of live pathogens and are associated with safety problems. Despite the success of vaccines, there is a clear need for novel antigen delivery technologies to improve vaccine efficacy and safety. Antigen stability, safety, and immunogenicity are the key hurdles in development of novel antigen delivery technologies. Nowadays, various novel drug delivery systems are becoming one of the fastest growing sectors in the pharmaceutical and biotechnological industries. Delivery of vaccines via oral, intranasal, transcutaneous, and intradermal routes will decrease the risk of needle-borne diseases and may eliminate the need for t...Continue Reading

References

Mar 1, 1991·Molecular Immunology·J H EldridgeR M Gilley
Jun 1, 1997·Transplantation Proceedings·J X WuW J Tze
Jul 1, 1997·The Journal of Pharmacy and Pharmacology·F A JohnsonA D Mercer
May 19, 1998·Nature Medicine·M A Liu
Aug 12, 1998·The Journal of Investigative Dermatology·T TütingL D Falo
Sep 19, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·N H ChoS Y Jeong
Mar 18, 1999·Journal of Clinical Immunology·K Palucka, J Banchereau
May 18, 1999·The American Journal of Pathology·A GebertA Weissferdt
May 26, 1999·Journal of Biomaterials Applications·M RamdasC P Sharma
Jun 24, 1999·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·S MurdanA T Florence
Jun 26, 1999·Seminars in Immunology·A Gebert, R Pabst
Oct 20, 1999·Methods : a Companion to Methods in Enzymology·G GregoriadisY Perrie
Nov 5, 1999·Nature Biotechnology·M Singh, D O'Hagan
Apr 15, 2000·Cellular and Molecular Life Sciences : CMLS·L J Hathaway, J P Kraehenbuhl
May 20, 2000·Journal of Microencapsulation·A EsquisabelJ L Pedraz
Jun 3, 2000·Biotechnology Progress·N KampfA Nussinovitch
Feb 28, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A R KulkarniW E Rudzinski
Jan 29, 2002·Journal of Microencapsulation·G CoppiR Cameroni
Feb 22, 2002·Journal of Biomedical Materials Research·Paul de VosHenk J Busscher
Jun 8, 2002·International Journal of Pharmaceutics·M González FerreiroR Bodmeier
Jul 24, 2002·Pharmaceutical Research·Manmohan Singh, Derek T O'Hagan
Aug 15, 2002·International Journal of Pharmaceutics·L ChanP Heng
Aug 6, 2004·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·A VilaM J Alonso
Oct 23, 2004·Pharmaceutical Research·Derek T O'Hagan, Rino Rappuoli
Jun 18, 2005·International Journal of Pharmaceutics·Camilla FogedAnne Sundblad
Jul 5, 2005·Expert Opinion on Investigational Drugs·G M GlennC R Alving

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Citations

Oct 18, 2016·Drug Delivery·Karmen Cheung, Diganta B Das
Mar 17, 2020·Drug Delivery and Translational Research·Arpit BhargavaPradyumna Kumar Mishra

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