PMID: 25739119Mar 5, 2015Paper

Novel antigens in non-small cell lung cancer: SP17, AKAP4, and PTTG1 are potential immunotherapeutic targets

Oncotarget
Leonardo MirandolaMaurizio Chiriva-Internati

Abstract

Lung cancer is the leading cause of cancer deaths in both genders worldwide, with an incidence only second to prostate cancer in men and breast cancer in women. The lethality of the disease highlights the urgent need for innovative therapeutic options. Immunotherapy can afford efficient and specific targeting of tumor cells, improving efficacy and reducing the side effects of current therapies. We have previously reported the aberrant expression of cancer/testis antigens (CTAs) in tumors of unrelated histological origin. In this study we investigated the expression and immunogenicity of the CTAs, Sperm Protein 17 (SP17), A-kinase anchor protein 4 (AKAP4) and Pituitary Tumor Transforming Gene 1 (PTTG1) in human non-small cell lung cancer (NSCLC) cell lines and primary tumors. We found that SP17, AKAP4 and PTTG1 are aberrantly expressed in cancer samples, compared to normal lung cell lines and tissues. We established the immunogenicity of these CTAs by measuring CTA-specific autoantibodies in patients' sera and generating CTA-specific autologous cytotoxic lymphocytes from patients' peripheral blood mononuclear cells. Our results provide proof of principle that the CTAs SP17/AKAP4/PTTG1 are expressed in both human NSCLC cell lines...Continue Reading

References

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Citations

Jun 1, 2018·Journal of Translational Medicine·Zehuan LiJin Wang
Sep 7, 2018·Immunotherapy·Joanne Ern Chi SohRahman Jamal
Jan 12, 2016·Therapeutic Advances in Medical Oncology·Gregory T WurzMichael W DeGregorio
Feb 27, 2020·Communications Biology·Alessio GrimaldiVincenzo Barnaba
Nov 2, 2017·Oncotarget·Leonardo MirandolaMaurizio Chiriva-Internati
Jun 16, 2016·Cancer Research·Carmen S TellezSteven A Belinsky
Apr 24, 2019·Molecular Therapy Oncolytics·Weiyang LouWeimin Fan
Feb 11, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Liza O'DonnellPeter G Stanton

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