Novel antiviral effect of lithium chloride on mammalian orthoreoviruses in vitro

Microbial Pathogenesis
Ye ChenChong Wang

Abstract

Reovirus not only causes considerable economic loss in the swine industry of the United States and other countries, but also threatens the public health due to its zoonotic potential. According to previous reports, LiCl has antiviral activity against a number of viruses. The inhibitory effects of LiCl on reovirus life cycle in Vero cells were evaluated. The unpaired t-test and one-way ANOVA were used to analyze the differences between experimental groups. We first found that LiCl treatment significantly inhibited reovirus replication in a dose-dependent manner. Furthermore, we found that this antiviral activity of LiCl targets the early stage of viral replication. LiCl could be a potential drug against reovirus infection.

References

May 15, 1989·Biochemical and Biophysical Research Communications·Z Ziaie, N A Kefalides
Nov 28, 1970·The Veterinary Record·L Kasza
Aug 28, 1968·Journal of Molecular Biology·Y WatanabeA F Graham
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 30, 2004·The Journal of Infectious Diseases·Kenneth L TylerTerence S Dermody
May 5, 2007·Avian Pathology : Journal of the W.V.P.A·Sally M HarrisonJulian A Hiscox
Jun 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kaw Bing ChuaLin-Fa Wang
Apr 10, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Peter ChengWilina Lim
Feb 11, 2015·Archives of Virology·Ye ChenJingchen Sun
May 21, 2015·MBio·Athmaram Thimmasandra NarayanappaSubbiah Elankumaran
Jun 13, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xiaozhan ZhangLiandong Qu

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Citations

Apr 9, 2017·Journal of Medical Virology·Fu-Rong ZhaoHui-Yun Chang
May 22, 2020·International Journal of Bipolar Disorders·Andrea MurruUNKNOWN International Group for The Study of Lithium Treated Patients (IGSLi)

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