Novel antiviral therapeutics to control foot-and-mouth disease

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Camila C A DiasMarvin J Grubman

Abstract

Foot-and-mouth disease virus (FMDV) causes a highly contagious disease of cloven-hoofed animals. Vaccines require ∼7 days to induce protection; thus, before this time, vaccinated animals are still susceptible to the disease. Our group has previously shown that swine inoculated with 1×10(11) focus forming units (FFU) of a replication-defective human adenovirus containing the gene for porcine interferon alpha (Adt-pIFN-α) are sterilely protected from FMDV serotypes A24, O1 Manisa, or Asia 1 when the animals are challenged 1 day postadministration, and protection can last for 3-5 days. Polyriboinosinic-polyribocytidylic acid stabilized with poly-l-lysine and carboxymethyl cellulose (poly ICLC) is a synthetic double-stranded RNA that is a viral mimic and activates multiple innate immune pathways through interaction with toll-like receptor 3 and MDA-5. It is a potent inducer of IFNs. In this study, we initially examined the effect of poly IC and IFN-α on FMDV replication and gene induction in cell culture. Poly ICLC alone or combined with Adt-pIFN-α was then evaluated for its therapeutic efficacy in swine against intradermal challenge with FMDV A24, 1 day post-treatment. Groups of swine were subcutaneously inoculated either with pol...Continue Reading

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Citations

May 9, 2014·Animal Health Research Reviews·Benjamin W NewcomerM Daniel Givens
Sep 23, 2014·Expert Review of Vaccines·Yimei Cao
Apr 2, 2016·Veterinary Immunology and Immunopathology·Stephen W MamberJoseph M Cummins
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Dec 3, 2014·Biochemical and Biophysical Research Communications·David J LefebvreKris De Clercq
Jun 1, 2016·Frontiers in Veterinary Science·Carolina StenfeldtJonathan Arzt
Jun 21, 2016·Transboundary and Emerging Diseases·L RobinsonW Vosloo
Jul 29, 2016·Journal of Virology·Lisbeth Ramírez-CarvajalTeresa de los Santos
Jul 18, 2014·Journal of Virology·Lisbeth Ramírez-CarvajalTeresa de los Santos
Jan 1, 2020·Virusdisease·Sarkar SoumajitVeerakyathappa Bhanuprakash
Aug 28, 2020·Frontiers in Veterinary Science·Gisselle N MedinaFayna Diaz-San Segundo

Methods Mentioned

BETA
blood drawn
ELISA
RIP

Related Concepts

Poly ICLC, sodium salt
Ichtadenovirus
Immunologic Adjuvants
Metazoa
Antiviral Agents
Biological Response Modifier Therapy
Ruspol
Cultured Cells
Foot-and-Mouth Disease
Cloning Vectors

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