Novel application method of artificial dermis: one-step grafting procedure of artificial dermis and skin, rat experimental study

Burns : Journal of the International Society for Burn Injuries
Kazutaka SoejimaMasaki Takeuchi

Abstract

Currently, to treat skin defects with artificial dermis (AD), two surgical procedures where the artificial dermis grafting and another secondary skin grafting are required. The purpose of this study was to achieve simultaneous grafting of the artificial dermis and the split-skin. To enhance the wound angiogenesis, cultured endothelial cells, fibroblasts and PDWHF (platelet derived wound healing factor) were employed. The experiment consists of following two parts: (1) Investigation to obtain faster angiogenesis into the bilayer artificial dermis: full-thickness wounds created on the back of the rats were treated with the artificial dermis (Terudermis, with silicone sheet, TERUMO Co., Japan). Prior to the artificial dermis grafting, following four groups were established; control group (AD alone, n=6), PDWHF group (AD treated with PDWHF, n=6), cultured cells group (AD treated with cultured endothelial cells and fibroblasts, n=6), combination group (AD treated with PDWHF and cultured cells, n=6). (2) Trial of one-stage grafting of the AD and the skin: simultaneous grafting of the artificial dermis and skin was performed using the same rat model. Before making skin defects, split thickness skin were harvested. Then the skin grafti...Continue Reading

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Citations

Oct 30, 2009·Journal of the Royal Society, Interface·Rostislav V ShevchenkoS Elizabeth James
Sep 17, 2015·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Tsutomu KashimuraHiroaki Nakazawa
Feb 23, 2010·Journal of the Chinese Medical Association : JCMA·Li-Tzu LeeYong-Kie Wong
Dec 17, 2009·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Xin ChenGuoan Zhang
Feb 18, 2015·Burns : Journal of the International Society for Burn Injuries·Xueyong LiJinqing Li
Aug 16, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Jung Min LeeChan Hum Park
Dec 23, 2008·The Journal of Craniofacial Surgery·Sung-No JungHo Kwon
Nov 6, 2020·International Journal of Molecular Sciences·Wasima Oualla-BachiriSalvador Arias-Santiago

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