Novel application of proton pump inhibitor for the prevention of colitis-induced colorectal carcinogenesis beyond acid suppression

Cancer Prevention Research
Yoon Jae KimKi Baik Hahm

Abstract

Colitis-associated cancers arise in the setting of chronic inflammation wherein an "inflammation-dysplasia-carcinoma" sequence prevails. Based on our previous findings in which the proton pump inhibitor could impose significant levels of anti-inflammatory, antiangiogenic, and selective apoptosis induction beyond gastric acid suppression, we investigated whether omeprazole could prevent the development of colitis-associated cancer in a mouse model induced by repeated bouts of colitis. Omeprazole, 10 mg/kg, was given i.p. all through the experimental periods for colitis-associated carcinogenesis. Molecular changes regarding inflammation and carcinogenesis were compared between control groups and colitis-associated cancer groups treated with omeprazole in addition to chemopreventive outcome. Nine of 12 (75.0%) mice in the control group developed multiple colorectal tumors, whereas tumors were noted in only 3 of 12 (25.0%) mice treated with daily injections of omeprazole. The cancer-preventive results of omeprazole treatment was based on significant decreases in the levels of nitric oxide, thiobarbituric acid-reactive substance, and interleukin-6 accompanied with attenuated expressions of tumor necrosis factor-alpha, inducible nitr...Continue Reading

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Citations

Mar 15, 2012·Journal of Gastroenterology and Hepatology·Yoon Jae KimKi Baik Hahm
Feb 25, 2014·Neoplasia : an International Journal for Oncology Research·Young-Min HanEun-Hee Kim
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Apr 6, 2013·Gut and Liver·Kyung-Soo ChunKi Baik Hahm
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Dec 10, 2020·Journal of Clinical Biochemistry and Nutrition·Young-Min HanKi Baik Hahm
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