Novel applications of mass spectrometry-based metabolomics in herbal medicines and its active ingredients: Current evidence

Mass Spectrometry Reviews
Xi-Jun WangLiang Liu

Abstract

Current evidence shows that herbal medicines could be beneficial for the treatment of various diseases. However, the complexities present in chemical compositions of herbal medicines are currently an obstacle for the progression of herbal medicines, which involve unclear bioactive compounds, mechanisms of action, undetermined targets for therapy, non-specific features for drug metabolism, etc. To overcome those issues, metabolomics can be a great to improve and understand herbal medicines from the small-molecule metabolism level. Metabolomics could solve scientific difficulties with herbal medicines from a metabolic perspective, and promote drug discovery and development. In recent years, mass spectrometry-based metabolomics was widely applied for the analysis of herbal constituents in vivo and in vitro. In this review, we highlight the value of mass spectrometry-based metabolomics and metabolism to address the complexity of herbal medicines in systems pharmacology, and to enhance their biomedical value in biomedicine, to shed light on the aid that mass spectrometry-based metabolomics can offer to the investigation of its active ingredients, especially, to link phytochemical analysis with the assessment of pharmacological effec...Continue Reading

References

Jan 5, 2002·Journal of Natural Products·J BradshawP J Sidebottom
Aug 24, 2007·Nature Reviews. Drug Discovery·Jane Qiu
Jan 1, 2008·Journal of Pharmaceutical and Biomedical Analysis·Xijun WangHongxin Cao
Jul 14, 2010·Journal of Mass Spectrometry : JMS·Hisayuki HoraiTakaaki Nishioka
Jul 27, 2010·Phytotherapy Research : PTR·Nancy Dewi YulianaRobert Verpoorte
Mar 2, 2011·PloS One·Nikolaos PsychogiosDavid S Wishart
Nov 16, 2012·Nature·Jeremy K NicholsonJohn C Lindon
Mar 20, 2013·Chemical Reviews·Naomi L Kuehnbaum, Philip Britz-McKibbin
Oct 22, 2013·Trends in Pharmacological Sciences·Xuan LiuDe-An Guo
Jan 1, 2013·Computational and Structural Biotechnology Journal·Mauro CommissoFlavia Guzzo
Jul 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Shao-Dan ChenRui-Zhi Zhao
Dec 4, 2014·Journal of Chromatography. a·Jean-Luc WolfenderSamuel Bertrand
Jan 24, 2015·Nature Reviews. Drug Discovery·Alan L HarveyRonald J Quinn
Apr 17, 2015·Mass Spectrometry Reviews·Mona M KhamisAnas El-Aneed
May 27, 2015·Cell Proliferation·Tao XieJian Huang

❮ Previous
Next ❯

Citations

Feb 7, 2020·Expert Opinion on Drug Discovery·Kevin Andrew StuartRuAngelie Edrada-Ebel
Apr 21, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Bernard K WanjohiWilson K Kipkore
Jul 13, 2019·Frontiers in Physiology·Jindřich ChmelařMichail Kotsyfakis
Jan 30, 2021·Natural Product Reports·Chang-Liang YaoDe-An Guo
Mar 23, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Jing GuoTomoyoshi Soga
Jul 16, 2021·European Journal of Pharmacology·Yuling TongYanling Zhao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.