Novel approach to antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG): randomised controlled trial.

BMJ : British Medical Journal
John BlombergJesper Lagergren

Abstract

To evaluate a new and simpler strategy of antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG). Single centre, two arm, randomised, controlled, double blind clinical trial. Endoscopy unit in Karolinska University Hospital, Stockholm, Sweden, between 3 June 2005 and 31 October 2009. 234 patients with an indication for PEG who gave informed consent to participate. A single 20 ml dose of the oral solution of sulfamethoxazole and trimethoprim (also known as co-trimoxazole or Bactrim; F Hoffmann-La Roche Ltd, Basel, Switzerland) deposited in the PEG catheter immediately after insertion. The control group received standard prophylaxis consisting of a single intravenous dose of 1.5 g cefuroxime (Zinacef; GlaxoSmithKline, London) administered before insertion of the PEG tube. Primary outcome was the occurrence of clinically evident wound infection within 14 days after insertion of the PEG catheter. Secondary outcomes were positive bacterial culture and blood tests (highly sensitive C reactive protein and white blood cell count). All randomised patients were included in an intention to treat analysis. Of the 234 patients included in this study, 116 were randomly assigned to co-trimoxazole and 118 to cefuroxime. At follow-...Continue Reading

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Citations

Sep 20, 2012·BMC Gastroenterology·Lena MartinPernilla Lagergren
Apr 5, 2012·Scandinavian Journal of Gastroenterology·John BlombergPernilla Lagergren
Oct 1, 2011·Scandinavian Journal of Gastroenterology·Matthew KurienDavid S Sanders
May 11, 2016·Scandinavian Journal of Gastroenterology·Lena MartinPernilla Lagergren
Feb 7, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Keith R MillerMatthew V Benns
Jan 19, 2013·Arquivos De Gastroenterologia·Helena DuarteJorge Fonseca
Sep 24, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Matthew L BechtoldDouglas L Nguyen
Feb 14, 2015·British Journal of Nursing : BJN·Anne Rowat
Jul 30, 2020·Minerva gastroenterologica e dietologica·Peter ElbeMiroslav Vujasinovic
Dec 31, 2016·BMC Obesity·Erik Norén, Henrik Forssell
Mar 25, 2019·Scandinavian Journal of Gastroenterology·Miroslav VujasinovicPeter Elbe
May 24, 2016·Journal of Veterinary Internal Medicine·J AguiarO A Garden
Oct 1, 2015·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Ana Belén Friginal-Ruiz, Alfredo J Lucendo
Mar 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Hilde KromAngelika Kindermann
Nov 9, 2020·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Elizabeth ZanleyTracey McLaughlin
Nov 6, 2020·Journal of Pediatric Gastroenterology and Nutrition·Francesco AlessandriGiovanni Di Nardo
Dec 1, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Matthew L BechtoldDouglas L Nguyen

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Methods Mentioned

BETA
sedation

Software Mentioned

SAS Statistical Package

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