Novel approach to antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG): randomised controlled trial.

BMJ : British Medical Journal
John BlombergJesper Lagergren


To evaluate a new and simpler strategy of antibiotic prophylaxis in percutaneous endoscopic gastrostomy (PEG). Single centre, two arm, randomised, controlled, double blind clinical trial. Endoscopy unit in Karolinska University Hospital, Stockholm, Sweden, between 3 June 2005 and 31 October 2009. 234 patients with an indication for PEG who gave informed consent to participate. A single 20 ml dose of the oral solution of sulfamethoxazole and trimethoprim (also known as co-trimoxazole or Bactrim; F Hoffmann-La Roche Ltd, Basel, Switzerland) deposited in the PEG catheter immediately after insertion. The control group received standard prophylaxis consisting of a single intravenous dose of 1.5 g cefuroxime (Zinacef; GlaxoSmithKline, London) administered before insertion of the PEG tube. Primary outcome was the occurrence of clinically evident wound infection within 14 days after insertion of the PEG catheter. Secondary outcomes were positive bacterial culture and blood tests (highly sensitive C reactive protein and white blood cell count). All randomised patients were included in an intention to treat analysis. Of the 234 patients included in this study, 116 were randomly assigned to co-trimoxazole and 118 to cefuroxime. At follow-...Continue Reading


Dec 1, 1980·Journal of Pediatric Surgery·M W GaudererR J Izant
Jan 29, 2000·Gastrointestinal Endoscopy·D KüllingP Bauerfeind
Nov 30, 2000·The American Journal of Gastroenterology·V K Sharma, C W Howden
Apr 9, 2002·Journal of Chemotherapy·S GeroulanosB Kadas
Mar 20, 2003·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·J H LeeK W Choi
Nov 5, 2003·Gastrointestinal Endoscopy·Stephen A McClave, Wei-Kuo Chang
Jul 25, 2006·The Journal of Hospital Infection·S MukhtarJ P Byrne
Oct 21, 2006·The Cochrane Database of Systematic Reviews·A Lipp, G Lusardi
Dec 7, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Kristina NormanMatthias Pirlich
May 9, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Alex CarignanLouis Valiquette
Dec 17, 2008·Journal of Clinical Nursing·Allyson Lipp, Gail Lusardi
Feb 19, 2009·International Journal of Clinical Practice·S MahadevaK-L Goh
May 6, 2009·Clinical Otolaryngology : Official Journal of ENT-UK ; Official Journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery·D G GrantM A Birchall
May 13, 2009·Gut·M C AllisonUNKNOWN Endoscopy Committee of the British Society of Gastroenterology

❮ Previous
Next ❯


Sep 20, 2012·BMC Gastroenterology·Lena MartinPernilla Lagergren
Apr 5, 2012·Scandinavian Journal of Gastroenterology·John BlombergPernilla Lagergren
Oct 1, 2011·Scandinavian Journal of Gastroenterology·Matthew KurienDavid S Sanders
May 11, 2016·Scandinavian Journal of Gastroenterology·Lena MartinPernilla Lagergren
Feb 7, 2014·JPEN. Journal of Parenteral and Enteral Nutrition·Keith R MillerMatthew V Benns
Jan 19, 2013·Arquivos De Gastroenterologia·Helena DuarteJorge Fonseca
Sep 24, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Matthew L BechtoldDouglas L Nguyen
Feb 14, 2015·British Journal of Nursing : BJN·Anne Rowat
Jul 30, 2020·Minerva gastroenterologica e dietologica·Peter ElbeMiroslav Vujasinovic
Dec 31, 2016·BMC Obesity·Erik Norén, Henrik Forssell
Mar 25, 2019·Scandinavian Journal of Gastroenterology·Miroslav VujasinovicPeter Elbe
May 24, 2016·Journal of Veterinary Internal Medicine·J AguiarO A Garden
Oct 1, 2015·Gastroenterology Nursing : the Official Journal of the Society of Gastroenterology Nurses and Associates·Ana Belén Friginal-Ruiz, Alfredo J Lucendo
Mar 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Hilde KromAngelika Kindermann
Nov 9, 2020·Surgery for Obesity and Related Diseases : Official Journal of the American Society for Bariatric Surgery·Elizabeth ZanleyTracey McLaughlin
Nov 6, 2020·Journal of Pediatric Gastroenterology and Nutrition·Francesco AlessandriGiovanni Di Nardo
Dec 1, 2016·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Matthew L BechtoldDouglas L Nguyen

❮ Previous
Next ❯

Methods Mentioned


Software Mentioned

SAS Statistical Package

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.