Novel Approaches for BAV Aortopathy Prediction-Is There a Need for Cohort Studies and Biomarkers?

Biomolecules
Evaldas GirdauskasTanja Zeller

Abstract

Bicuspid aortic valve (BAV) disease is the most common congenital malformation of the human heart with a prevalence of 1⁻2% in the general population. More than half of patients with a BAV present with a dilated proximal aorta (so-called bicuspid aortopathy) which is associated with an enhanced risk of life-threatening aortic complications. Up to now, the pathogenesis of bicuspid aortopathy as well as the risk stratification of aortic complications has not yet been sufficiently clarified. Recent findings have shown that bicuspid aortopathy features phenotypic heterogeneity. Two distinct valvulo-aortic phenotypes, the so-called root phenotype, as well as a dilation of the tubular ascending aorta, coincide with a significantly different risk for aortal complications. However, the phenotype-based classification that is only based on these two clinical forms is not sufficient to estimate the risk of aortal complications in a prognostically relevant way. Therefore, there is growing clinical interest to assess novel approaches in BAV research and to introduce circulating biomarkers as an elegant diagnostic tool to improve risk stratification in BAV aortopathy. A large scale epidemiological cohort study, ranking from apparently health...Continue Reading

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Citations

Sep 30, 2018·Biophysics Reviews·Stefanie S PortelliRichmond W Jeremy
Jun 6, 2020·Asian Cardiovascular & Thoracic Annals·Shiho NaitoEvaldas Girdauskas
May 18, 2019·Current Problems in Cardiology·Chiara MozziniMaurizio Soresi
Dec 10, 2020·International Journal of Molecular Sciences·Raquel Figuinha VideiraInês Falcão-Pires

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Methods Mentioned

BETA
dissection
imaging techniques

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