PMID: 11605183Oct 18, 2001Paper

Novel approaches for the treatment of non-small cell lung cancer

Seminars in Oncology
P Bonomi

Abstract

Non-small cell lung cancer is a major worldwide health problem. Approximately 80% of non-small cell lung cancer patients present with advanced disease for which there is little or no chance of cure. Although survival in stage IV non-small cell lung cancer patients is prolonged by treatment with combination chemotherapy regimens, all of these patients develop disease that is refractory to currently available systemic therapy. Basic scientists have identified a number of new therapeutic targets that offer the potential for novel therapeutic interventions, which might control chemotherapy-refractory disease or potentiate the effectiveness of chemotherapy and radiation therapy. The new targets include tumor-associated angiogenesis, biochemical pathways that stimulate tumor proliferation, and programmed cell death (apoptosis). Each of these novel targets will be discussed briefly in this review.

Citations

Nov 27, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·M MonzoM Taron
Jul 20, 2002·Current Opinion in Oncology·Louise Medley, Michael Cullen
Jun 6, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Dou YuGuo Shun-Lin

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