Novel archetype in psoriasis management bridging molecular dynamics in exploring novel therapies.

European Journal of Pharmacology
Krishna YadavManju Rawat Singh

Abstract

Psoriasis is an autoimmune chronic inflammatory condition of skin affecting 125 million populaces around the globe. It is implicated as a result of multifaceted phenomena involving various cell and subcell activities with the aid of numerous cellular and molecular components including signaling aisle and regulatory proteins owing to the development of such hyperproliferative dermatological conditions. This involves a deeply complex and conflicting pathology owing to genetic and immunological deviations resulting from the unusual presentation of different signaling pathways and regulatory proteins. Explorations of these biomarkers and intervention of molecular and cellular processes in psoriasis are yet to be investigated and could be an exceptional aspect for understanding pathology with successful targeting of disease. In the presented study, we have integrated molecular insights, including signaling molecules, pathways, and proteins implicated in pathogenesis, and we have attempted to link this knowledge to the targeting of these phenomena in order to manage the conditions precisely. Further, therapeutic delivery approaches for targeting distinct layers of skin have also been investigated based on the application of different...Continue Reading

References

Jun 14, 2002·Journal of the American Academy of Dermatology·Rudolf E SchopfJürgen Knop
Aug 12, 2004·The Journal of Investigative Dermatology·Christina SiemesVolker Herzog
Mar 3, 2005·Experimental Dermatology·Hanna MartinssonCharlotta Enerbäck
Apr 28, 2005·The Journal of Biological Chemistry·Eniko SonkolyMarta Szell
Jun 8, 2006·Health and Quality of Life Outcomes·Monali J BhosleRajesh Balkrishnan
Sep 13, 2006·Clinics in Dermatology·Wendy A MyersPhilip Mease
Mar 9, 2007·International Journal of Dermatology·Laura E Tovar-CastilloMario E Cancino-Díaz
Jul 20, 2007·The Journal of Investigative Dermatology·Malgorzata RomanowskaJohn Foerster
Aug 28, 2007·Journal of Dermatological Science·A ParadisiR Capizzi
Sep 22, 2007·Journal of Controlled Release : Official Journal of the Controlled Release Society·Vaibhav DubeyN K Jain
Oct 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Esmerina TiliCarlo Maria Croce
Jan 21, 2009·European Journal of Dermatology : EJD·Kaiming ZhangXuping Niu
Jul 31, 2009·The Journal of Investigative Dermatology·John R ZibertMariam Grigorian
Sep 16, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Honglin WangThomas Simmet
Aug 31, 2010·Current Opinion in Pharmacology·S Stoney Simons
Oct 19, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Priya BathejaBozena Michniak-Kohn
Oct 19, 2010·Nature Genetics·Eva EllinghausAndre Franke
Mar 18, 2011·The Journal of Investigative Dermatology·Ning XuAndor Pivarcsi
Apr 21, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·M DavidP Fishman
May 21, 2011·Experimental and Molecular Pathology·Ma Wei-yuanSun Qing
Jul 1, 2011·European Journal of Dermatology : EJD·Peng ZhangQianjin Lu
Sep 6, 2011·Journal of Dermatological Science·Larissa LarsenFu-Tong Liu
Oct 29, 2011·Drug Discovery Today·Pnina FishmanKenneth A Jacobson
Jan 25, 2012·The Journal of Pathology·H de la FuenteFrancisco Sanchez-Madrid
Mar 6, 2012·Journal of the American Academy of Dermatology·Jacinto Orgaz-MolinaSalvador Arias-Santiago
Apr 24, 2012·American Journal of Human Genetics·Catherine T JordanAnne M Bowcock
Sep 28, 2012·The British Journal of Dermatology·A HaldC Johansen
Oct 2, 2012·Nature Reviews. Drug Discovery·Pierre Miossec, Jay K Kolls
Dec 21, 2012·Nature·Ken Garber
Jan 11, 2013·The British Journal of Dermatology·K A PappUNKNOWN ACCEPT Investigators
Apr 19, 2013·Journal of Drug Targeting·Udita AgrawalN K Jain
May 28, 2013·Cellular Signalling·Shougang Zhuang
Sep 17, 2013·International Journal of Pharmaceutics·Line Hollesen BasseJoke A Bouwstra
Nov 12, 2013·Nature Genetics·Huayang TangXuejun Zhang

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Academy of Nurse Practitioners
E Frankel
Seminars in Cutaneous Medicine and Surgery
E M Altman, H Kamino
Free Radical Biology & Medicine
Qiang ZhouMartin Rostami-Yazdi
Biomedical Reports
Teodora Larisa Timis, Remus Ioan Orasan
© 2021 Meta ULC. All rights reserved