Novel aspects on signal-transduction in the pancreatic beta-cell

Nutrition, Metabolism, and Cardiovascular Diseases : NMCD
Per-Olof Berggren, Ingo B Leibiger

Abstract

The glucose-stimulus/insulin-secretion-coupling by the pancreatic beta-cell, which guarantees the maintenance of glucose homeostasis in man, is regulated by a sophisticated interplay between glucose and a plethora of additional factors. Besides other nutrients, incretins, nerval innervation, systemic growth factors as well as autocrine and paracrine regulatory loops within the islet of Langerhans modulate the function of the insulin-producing beta-cell. Although the modulatory role of these factors is well appreciated, the underlying molecular mechanisms involved remain poorly understood. However, in most cases beta-cell membrane receptors coupled primarily to either G-proteins or tyrosine kinases, which subsequently activate respective second messenger cascades, are involved. In the present mini-review we will discuss the role of signaling through some of these receptor-operated effector systems in the light of pancreatic beta-cell signal-transduction.

References

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Citations

Mar 11, 2008·Nature Medicine·Stephan SpeierPer-Olof Berggren
Nov 6, 2009·Endocrine Reviews·Anjaneyulu Kowluru
Jun 25, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Ki-Wook KimJong-Bae Kim
Jun 30, 2006·Current Opinion in Cell Biology·Barbara BorgonovoMichele Solimena
Oct 24, 2007·Biochimica Et Biophysica Acta·Céline Guiraud-DoganGeneviève Gourdon
Feb 17, 2017·Biochemical Pharmacology·Anjaneyulu Kowluru
Sep 8, 2017·Diabetes, Obesity & Metabolism·Anjaneyulu Kowluru
Sep 1, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zuzana BacováVladimir Strbák

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