Novel associations between sex hormones and diabetic vascular complications in men and postmenopausal women: a cross-sectional study

Cardiovascular Diabetology
Chiyu WangYingli Lu

Abstract

Associations between sex hormones and vascular remodeling have been extensively studied, but the results vary widely among different races and sex. We aimed to investigate whether total testosterone (TT), estrogen (E2), and dehydroepiandrosterone (DHEA) associate with macrovascular complications and diabetic kidney disease (DKD) among community-dwelling patients with diabetes. A total of 4720 participants with type 2 diabetes were recruited from Shanghai, China. Common carotid artery (CCA) plaques and diameter were assessed by ultrasound. Cardiovascular disease (CVD) was defined by prior diagnosis of coronary heart disease, myocardial infarction or stroke. DKD was defined according to the ADA Guidelines. (1) In men, TT was negatively associated with CCA diameter (regression coefficient (β) - 0.044, 95% CI - 0.087, 0). E2 levels were positively associated with CVD and CCA plaque prevalence (OR 1.151, 95% CI 1.038, 1.277 and OR 1.13, 95% CI 1.017, 1.255, respectively). DHEA was negatively associated with CVD (OR 0.809, 95% CI 0.734, 0.893). In postmenopausal women, TT levels were negatively associated with CCA diameter (β - 0.046, 95% CI - 0.083, - 0.010) and positively associated with CVD (OR 1.154, 95% CI 1.038, 1.284). (2) In ...Continue Reading

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Citations

Feb 19, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Camila Manrique-AcevedoDavid Gozal
Apr 28, 2020·Journal of Diabetes Research·Yi ChenYingli Lu
Jan 23, 2021·Molecular and Cellular Endocrinology·Melina A PagottoLiliana A Monasterolo
Feb 20, 2021·Environmental Pollution·Bin WangYingli Lu
Jun 11, 2021·Environmental Science and Pollution Research International·Haojie ZhangYingli Lu
Jun 22, 2021·International Journal of Endocrinology·João Martin MartinsCatarina Mota

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Methods Mentioned

BETA
hormone replacement therapy

Software Mentioned

EpiData
SPSS Statistics

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