Novel autophagy inducers lentztrehaloses A, B and C

The Journal of Antibiotics
Shun-ichi WadaAkio Nomoto

Abstract

Trehalose has widespread use as a sweetener, humectant and stabilizer, and is now attracting attention as a promising candidate for the treatment of neurodegenerative diseases as it is an autophagy inducer and chemical chaperone. However, the bioavailability of trehalose is low because it is digested by the hydrolyzing enzyme trehalase, expressed in the intestine and kidney. Enzyme-stable analogs of trehalose would potentially solve this problem. We have previously reported an enzyme-stable analog of trehalose, lentztrehalose, and herein report two new analogs. The original lentztrehalose has been renamed lentztrehalose A and the analogs named lentztrehaloses B and C. Lentztrehalose B is a di-dehydroxylated analog and lentztrehalose C is a cyclized analog of lentztrehalose A. All the lentztrehaloses are only minimally hydrolyzed by mammalian trehalase. The production of the lentztrehaloses is high in rather dry conditions and low in wet conditions. Lentztrehalose B shows a moderate antioxidative activity. These facts suggest that the lentztrehaloses are produced as humectants or protectants for the producer microorganism under severe environmental conditions. All the lentztrehaloses induce autophagy in human cancer cells at a c...Continue Reading

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Jan 23, 2014·The Journal of Antibiotics·Shun-ichi WadaAkio Nomoto

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Citations

Nov 3, 2015·Chemical & Pharmaceutical Bulletin·Ming ZhangMasakatsu Shibasaki
Sep 7, 2016·Journal of Agricultural and Food Chemistry·Shun-Ichi WadaMasayuki Igarashi
Dec 12, 2017·Pure and Applied Chemistry. Chimie Pure Et Appliquée·Mara K O'NeillBenjamin M Swarts
Aug 31, 2017·The Journal of Antibiotics·Manabu KawadaShuichi Sakamoto
Sep 5, 2019·Basic & Clinical Pharmacology & Toxicology·Kuan LiuBin Xu
Nov 11, 2020·Natural Product Reports·Jeffrey D RudolfZining Li
Aug 10, 2021·Archives of Microbiology·Zainab AbdelghaniRouba Hage-Sleiman

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