Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity.

ACS Medicinal Chemistry Letters
Qiang WangKuo-Hsiung Lee

Abstract

Novel betulinic/betulonic acid-nucleoside hybrids were synthesized as possible new anti-HIV agents. Among the synthesized hybrids, two compounds were highly effective against HIV. Compared with AZT and DSB, compounds 10a (IC50 = 0.0078 μM, CC50 = 9.6 μM) and 10b (IC50 = 0.020 μM, CC50 = 23.8 μM) showed more potent or equipotent, respectively, anti-HIV activity but displayed lower cytotoxicity.

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Citations

Mar 7, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·André Barreto CunhaJorge Mauricio David
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Daniela PerroneMaria Luisa Navacchia

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