Novel bioactive peptides demonstrating anti-dengue virus activity isolated from the Asian medicinal plant Acacia Catechu

Chemical Biology & Drug Design
Aussara PanyaPa-Thai Yenchitsomanus

Abstract

The therapeutic activities of food-derived bioactive proteins and peptides are attracting increased attention within the research community. Medicinal plants used in traditional medicines are an excellent source of bioactive proteins and peptides, especially those traditionally prepared by water extraction for use as tea or food supplement. In this study, novel bioactive peptides were isolated from enzymatic digests of 33 Thai medicinal plants. The inhibitory activity of each against dengue virus (DENV) infection was investigated. Of 33 plants, peptides from Acacia catechu extract demonstrated the most pronounced anti-DENV activity. Half maximal inhibitory concentration of 0.18 μg/ml effectively inhibited DENV foci formation. Treatment with 1.25 μg/ml crude peptide extract could reduce virus production less than 100-fold with no observable cell toxicity. Peptide sequences were determined by high-performance liquid chromatography and liquid chromatography-tandem mass spectrometry. Two bioactive peptides isolated from Acacia catechu inhibited DENV foci formation >90% at the concentration of 50 μM; therefore, they are recommended for further investigation as antiviral peptides against DENV infection.

References

Mar 1, 2000·Trends in Biochemical Sciences·C CombetG Deléage
Apr 3, 2003·Phytotherapy Research : PTR·Supinya TewtrakulSukanya Dej-Adisai
Aug 9, 2005·Journal of Ethnopharmacology·Pornpen PramyothinChaiyo Chaichantipyuth
Mar 18, 2009·Microbiology and Immunology·Mali WirotesangthongChutichot Mungmee
Oct 14, 2009·Clinical Microbiology Reviews·Byron E E MartinaAlbert D M E Osterhaus
Jan 6, 2012·Plant Cell Reports·Chiara LicoLinda Avesani
Jun 16, 2012·Pharmacognosy Magazine·Bhaskarmurthy Deepak HiraganahalliAmit Agarwal
Jan 25, 2013·Molecular Therapy. Nucleic Acids·Peter JärverMichael J Gait
Mar 7, 2014·Parasitology Research·Warachate KhobjaiVoravuth Somsak
Mar 13, 2014·Chemical Biology & Drug Design·Aussara PanyaPa-Thai Yenchitsomanus
May 20, 2014·Pharmacology, Biochemistry, and Behavior·Wanvisa BoonyarikpunchaiPasarapa Towiwat
Nov 5, 2014·The New England Journal of Medicine·Luis VillarUNKNOWN CYD15 Study Group
Dec 3, 2014·Drug Discovery Today·Keld Fosgerau, Torsten Hoffmann
Mar 25, 2015·Phytotherapy Research : PTR·Sidney J Stohs, Debasis Bagchi
Mar 31, 2015·BioMed Research International·Carlos E SalasCarmen Oliver-Salvador
Nov 7, 2015·Antiviral Research·Thidarath RattanabureePa-thai Yenchitsomanus
Nov 19, 2015·Pharmaceuticals·James P TamWei Liang Tan
Apr 20, 2016·Scientific Reports·Faiza Hanif WaghuSusan Idicula-Thomas
Sep 3, 2017·Virus Research·Mayuri TarasukPa-Thai Yenchitsomanus
Dec 21, 2017·Archives of Virology·Patta PhumesinPa-Thai Yenchitsomanus

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Citations

Aug 24, 2019·Protein Science : a Publication of the Protein Society·Faiza Hanif Waghu, Susan Idicula-Thomas
May 20, 2020·International Journal of Peptide Research and Therapeutics·Garima Agarwal, Reema Gabrani
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aussara PanyaPa-Thai Yenchitsomanus
Aug 29, 2021·Pharmaceuticals·Nour Mammari On Behalf Of The Oemonom

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