Novel biological markers of bone: from bone metabolism to bone physiology

Rheumatology
Roland D Chapurlat, Cyrille B Confavreux

Abstract

Biochemical markers of bone turnover have been used for decades in the management of bone diseases, to assess the prognosis of these conditions and to monitor treatments. The new markers, however, also reflect specific physiological mechanisms in the bone or other organs. Periostin may be more specific to the periosteum; cathepsin K is an osteoclastic enzyme that may be involved in the cardiovascular system and joints; Dickkopf-1 is involved in bone formation and vascular calcification; sclerostin is a major regulator of bone formation in response to mechanical loading and may also play a role in chronic kidney disease bone and mineral disorder; sphingosine-1-phosphate is a lipid mediator interacting with bone resorption. Some of the bone markers are in fact hormones produced by the bone that affect various physiological and pathological functions in other organs. Thus, osteocalcin is produced by osteoblasts and participates in the regulation of insulin sensitivity and fertility in men. Fibroblast growth factor 23 is produced by osteocytes to regulate phosphorus and 1,25(OH)2D3, but it also plays a major role in the adverse consequences of declining renal function, in particular with respect to the myocardium. Micro RNAs are si...Continue Reading

References

Mar 1, 1990·Calcified Tissue International·D VanderschuerenJ Dequeker
Jul 1, 1989·Physiological Reviews·P V HauschkaC M Gundberg
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S A KernerJ W Pike
Apr 1, 1985·The Journal of Clinical Endocrinology and Metabolism·C M GundbergJ F Rosen
Jul 15, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K HoriuchiA Kudo
Sep 12, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R D ChapurlatP D Delmas
Mar 30, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R A DoddsM Gowen
Jul 23, 2003·The Journal of Biological Chemistry·Shiguang LiuL Darryl Quarles
Dec 26, 2003·The New England Journal of Medicine·Erming TianJohn D Shaughnessy
Mar 26, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takashi ShimadaTakeyoshi Yamashita
Oct 30, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Volkhard LindnerCalvin P H Vary
Dec 4, 2004·Development·Hongliang HuFanxin Long
May 4, 2005·Developmental Cell·Donald A GlassGerard Karsenty
May 4, 2006·The Journal of Clinical Investigation·Venkatesh KrishnanOrmond A Macdougald
Jul 25, 2006·Cardiovascular Research·Thomas BradeMichael Kühl
Nov 7, 2006·Nature·Itaru UrakawaTakeyoshi Yamashita
Jan 24, 2007·Nature Medicine·Danielle DiarraGeorg Schett
Aug 19, 2007·Cell·Na Kyung LeeGerard Karsenty
Aug 21, 2007·Journal of Bone and Mineral Metabolism·Makoto HiraoHideki Yoshikawa
Sep 19, 2007·British Journal of Cancer·N Voorzanger-RousselotP Garnero
Oct 2, 2007·Arthritis and Rheumatism·Nancy E LaneUNKNOWN Study of Osteoporotic Fractures Research Group
Nov 27, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Hamish DobbieDavid G Shirley
Jul 17, 2008·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·P Szulc, P D Delmas
Aug 5, 2008·Joint, Bone, Spine : Revue Du Rhumatisme·Daniel WendlingEvelyne Racadot
Aug 9, 2008·The New England Journal of Medicine·Orlando M GutiérrezMyles Wolf
Sep 12, 2008·Proceedings of the National Academy of Sciences of the United States of America·Zhaoyong LiGary S Stein
Nov 6, 2008·The Journal of Clinical Endocrinology and Metabolism·Ippei KanazawaToshitsugu Sugimoto
Dec 18, 2008·The Journal of Clinical Endocrinology and Metabolism·Anastassios G PittasBess Dawson-Hughes
Jun 16, 2009·The Journal of Surgical Research·Yanan ZhangWenhao Tang
Oct 13, 2009·Maturitas·Manuel Muñoz-TorresFernando Escobar-Jiménez
Oct 17, 2009·Clinical Endocrinology·Athanasios D AnastasilakisEvangelos Terpos

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Citations

Aug 3, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nicolas BonnetSerge L Ferrari
Aug 21, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Despina D BrianaAriadne Malamitsi-Puchner
Apr 25, 2020·Biosensors·Seema RaniGuozhen Liu
Jul 27, 2017·Stem Cells International·Donatella GranchiGabriela Ciapetti
Oct 27, 2017·Calcified Tissue International·Cyrille B Confavreux
Jul 26, 2018·Physiological Research·I Zofkova
Sep 13, 2018·Journal of Periodontal Research·Carolina Bizelli-SilveiraDavid C E Kraft
Aug 4, 2019·Aging Clinical and Experimental Research·Weibo XiaJean-Yves Reginster
Aug 15, 2020·International Urology and Nephrology·Davide BolignanoGiuseppe Coppolino
Oct 16, 2019·International Urology and Nephrology·Andreja FigurekGoce Spasovski
Jun 26, 2017·Clinical Oral Investigations·Gustavo Davi RabeloFabio Abreu Alves
Dec 13, 2016·Current Treatment Options in Allergy·Anna James, Gunilla Hedlin
Jul 14, 2020·Journal of Nephrology·Davide BolignanoGiuseppe Coppolino
Aug 3, 2018·Pediatric Allergy, Immunology, and Pulmonology·Amelia LicariGiorgio Ciprandi
Feb 3, 2021·Nature Reviews. Rheumatology·Christopher D BuckleyKim S Midwood
Jul 21, 2020·European Journal of Dentistry·Agung Satria WardhanaMeircurius Dwi Condro Surboyo
Mar 17, 2020·Research in Veterinary Science·Fumi YamaguchiMakoto Fujiki

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