Novel biomarkers of prenatal methamphetamine exposure in human meconium.

Therapeutic Drug Monitoring
Teresa R GrayMarilyn A Huestis

Abstract

Meconium analysis can detect fetal exposure to drugs taken by the mother during pregnancy. Methamphetamine (MAMP) and amphetamine (AMP) have previously been observed in meconium of MAMP-exposed neonates; the presence of other metabolites has not been investigated. Detection of such analytes may lead to more sensitive identification and thus improved medical treatment of affected infants. Forty-three MAMP-positive meconium specimens were analyzed for newly identified MAMP biomarkers, p-hydroxymethamphetamine, p-hydroxyamphetamine, and norephedrine. Due to MAMP adulteration in illicit ecstasy and to simultaneously monitor 3,4-methylenedioxymethamphetamine and MAMP prenatal exposure, 3,4-methylenedioxymethamphetamine, its metabolites, and related sympathomimetic amines were assayed. MAMP, AMP, and unconjugated p-hydroxymethamphetamine were the most prevalent and abundant analytes present in meconium; however, unconjugated p-hydroxyamphetamine and norephedrine also were identified. It is possible that one of these additional analytes could be important for predicting toxicity or maternal or neonatal outcome measures in fetuses exposed to MAMP at specific gestational ages or with different metabolic capabilities. Although these new ...Continue Reading

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Citations

Dec 15, 2010·Journal of Perinatology : Official Journal of the California Perinatal Association·T E WrightA C Collier
Sep 4, 2012·Clinics in Laboratory Medicine·Donald L Frederick
Jul 19, 2016·Journal of Pharmaceutical and Biomedical Analysis·Laura Mercolini, Michele Protti
Jan 8, 2015·Therapeutic Drug Monitoring·Gwendolyn A McMillinMatthew D Krasowski
Feb 9, 2018·Therapeutic Drug Monitoring·Simuli L WabuyeleGwendolyn A McMillin
Sep 1, 2010·Obstetric Medicine·Katherine Scott, Karin Lust
Aug 17, 2021·Journal of Clinical Pharmacology·Jessica M BarryCatherine M Sherwin

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