PMID: 9435101Jan 22, 1998Paper

Novel bismuth compounds have in vitro activity against Helicobacter pylori

FEMS Microbiology Letters
P MidoloJ R Lambert

Abstract

The increasing antimicrobial resistance in Helicobacter pylori has led to the search for new therapeutic agents. In this in vitro study, novel compounds combining bismuth with sialic acid inhibitors were investigated for bactericidal activity using time-kill methodology. The activity of these compounds was compared to bismuth subcitrate against a type strain and a clinical isolate of H. pylori. The compounds tested showed cidal activity which was related to the bismuth component of each drug. These compounds may offer a potential advantage over current bismuth preparations with the sialic acid inhibitor moiety interfering with adhesion of H. pylori to gastric epithelium.

Citations

Jun 23, 1999·The Yale Journal of Biology and Medicine·J A Louw, I N Marks
Feb 1, 2005·FEMS Immunology and Medical Microbiology·Yuan-Chuen Wang, Tung-Liang Huang
Feb 15, 2005·FEMS Immunology and Medical Microbiology·Yuan-Chuen Wang, Tung-Liang Huang
Aug 19, 2014·World Journal of Gastroenterology : WJG·Yuan-Chuen Wang

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