Novel blaROB-1-bearing plasmid conferring resistance to β-lactams in Haemophilus parasuis isolates from healthy weaning pigs

Applied and Environmental Microbiology
Javier MoleresJunkal Garmendia

Abstract

Haemophilus parasuis, the causative agent of Glässer's disease, is one of the early colonizers of the nasal mucosa of piglets. It is prevalent in swine herds, and lesions associated with disease are fibrinous polyserositis and bronchopneumonia. Antibiotics are commonly used in disease control, and resistance to several antibiotics has been described in H. parasuis. Prediction of H. parasuis virulence is currently limited by our scarce understanding of its pathogenicity. Some genes have been associated with H. parasuis virulence, such as lsgB and group 1 vtaA, while biofilm growth has been associated with nonvirulent strains. In this study, 86 H. parasuis nasal isolates from farms that had not had a case of disease for more than 10 years were obtained by sampling piglets at weaning. Isolates were studied by enterobacterial repetitive intergenic consensus PCR and determination of the presence of lsgB and group 1 vtaA, biofilm formation, inflammatory cell response, and resistance to antibiotics. As part of the diversity encountered, a novel 2,661-bp plasmid, named pJMA-1, bearing the blaROB-1 β-lactamase was detected in eight colonizing strains. pJMA-1 was shown to share a backbone with other small plasmids described in the Pasteu...Continue Reading

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Citations

Mar 23, 2017·Frontiers in Microbiology·Janine T BosséPaul R Langford
Nov 30, 2016·Antimicrobial Agents and Chemotherapy·Alfonso Santos-LopezBruno Gonzalez-Zorn
Apr 12, 2017·Antimicrobial Agents and Chemotherapy·Cristina M OvejeroBruno Gonzalez-Zorn
Dec 13, 2019·Frontiers in Cellular and Infection Microbiology·Hossam AbdelhamedMark L Lawrence
Aug 3, 2019·BMC Veterinary Research·Xiao-Dong LiDao-Jin Yu
Jun 20, 2018·Microbiology Spectrum·Geovana B MichaelStefan Schwarz

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