Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery

Chemical Science
Yao SunXuechuan Hong

Abstract

Though high brightness and biocompatible small NIR-II dyes are highly desirable in clinical or translational cancer research, their fluorescent cores are relatively limited and their synthetic processes are somewhat complicated. Herein, we have explored the design and synthesis of novel NIR-II fluorescent materials (H1) without tedious chromatographic isolation with improved fluorescence performance (QY ≈ 2%) by introducing 2-amino 9,9-dialkyl-substituted fluorene as a donor into the backbone. Several types of water-soluble and biocompatible NIR-II probes: SXH, SDH, and H1 NPs were constructed via different chemical strategies based on H1, and then their potential to be used in in vivo tumor imaging and image-guided surgery in the NIR-II region was explored. High levels of uptake were obtained for both passive and active tumor targeting probes SXH and SDH. Furthermore, high resolution imaging of blood vessels on tumors and the whole body of living mice using H1 NPs for the first time has demonstrated precise NIR-II image-guided sentinel lymph node (SLN) surgery.

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Citations

Jul 28, 2018·Advanced Healthcare Materials·Xiaodong ZengXuechuan Hong
Aug 8, 2018·Nature Nanotechnology·Yong FanFan Zhang
Jan 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Yue SunPeter J Stang
Feb 12, 2019·Chemical Communications : Chem Comm·Xiaodong ZengYuling Xiao
Apr 27, 2019·Advanced Materials·Shoujun ZhuHongjie Dai
Oct 9, 2019·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiaoming YuGonghui Li
Mar 12, 2019·Frontiers in Chemistry·Krzysztof B Beć, Christian W Huck
Dec 4, 2019·Advanced Healthcare Materials·Hui ZhouXuechuan Hong
Jul 30, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Lina WuXilin Sun
Nov 7, 2019·Frontiers in Chemistry·Yizhou LiAixi Yu
Jun 27, 2018·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Madeline T OlsonAaron M Mohs
Feb 6, 2020·Chemical Communications : Chem Comm·Ji-An ChenXianfeng Gu
Dec 5, 2019·Frontiers in Bioengineering and Biotechnology·Qing LiMingyuan Gao
Dec 31, 2019·Advanced Functional Materials·Hao WanHongjie Dai
Nov 8, 2019·Advanced Healthcare Materials·Yongkuan SuoZhen Cheng
Sep 15, 2018·Scientific Reports·Vitalijs ZubkovsArdemis A Boghossian
Jul 22, 2019·Nanoscale Research Letters·A YakovlievT Y Ohulchanskyy
Feb 19, 2019·Chemical Science·Jiacheng LinXuechuan Hong
Mar 13, 2020·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Nicholas E Wojtynek, Aaron M Mohs
Sep 29, 2020·Advanced Optical Materials·Chunrong QuXuechuan Hong
Jan 17, 2020·Advanced Healthcare Materials·Ling'e ZhangXiqun Jiang
Jul 12, 2019·Advanced Drug Delivery Reviews·Colman MooreJesse V Jokerst
Aug 12, 2020·Angewandte Chemie·Zuhai Lei, Fan Zhang

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Methods Mentioned

BETA
fluorescence imaging
NMR
surgical resection
fluorescence
transmission electron microscopy
dynamic light scattering

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