Novel burn device for rapid, reproducible burn wound generation

Burns : Journal of the International Society for Burn Injuries
J Y KimHeather M Powell

Abstract

Scarring following full thickness burns leads to significant reductions in range of motion and quality of life for burn patients. To effectively study scar development and the efficacy of anti-scarring treatments in a large animal model (female red Duroc pigs), reproducible, uniform, full-thickness, burn wounds are needed to reduce variability in observed results that occur with burn depth. Prior studies have proposed that initial temperature of the burner, contact time with skin, thermal capacity of burner material, and the amount of pressure applied to the skin need to be strictly controlled to ensure reproducibility. The purpose of this study was to develop a new burner that enables temperature and pressure to be digitally controlled and monitored in real-time throughout burn wound creation and compare it to a standard burn device. A custom burn device was manufactured with an electrically heated burn stylus and a temperature control feedback loop via an electronic microstat. Pressure monitoring was controlled by incorporation of a digital scale into the device, which measured downward force. The standard device was comprised of a heat resistant handle with a long rod connected to the burn stylus, which was heated using a ho...Continue Reading

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Citations

Jul 7, 2016·Molecular Therapy. Methods & Clinical Development·Ayesha BhatiaWei Li
Sep 10, 2016·PloS One·Christine J AndrewsLeila Cuttle
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Apr 23, 2020·Advances in Wound Care·Danielle M DeBrulerHeather M Powell
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Nov 27, 2019·Burns : Journal of the International Society for Burn Injuries·Molly E BaumannHeather M Powell
Jul 3, 2021·Biology·Dandan Hao, Mahtab Nourbakhsh

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