Novel case of ocular neuromyotonia associated with thyroid-related orbitopathy and literature review

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Andrea Susan GiardinaDaniel R Eckermann


To present a novel case of pupillary involvement in ocular neuromyotonia (ONM), a rare ocular syndrome that causes intermittent diplopia because of an abnormal delay in extraocular muscle relaxation and to conduct a literature review. A case report is presented to demonstrate clinical characteristics and treatment of ONM. In addition, a literature review is conducted by searching Medline and Embase databases. Data are collected from all known published cases listed in these databases to collate patient demographic data, presumed etiology or associated pathologies, and treatment strategies. The presented case demonstrates successful carbamazepine treatment of thyroid-related orbitopathy-associated ONM involving cranial nerve III. A review of the literature elicits 66 published cases of ONM, three of which were deemed to be associated with thyroid-related orbitopathy. The most common cause of reported ONM is suprasellar pathology, comprising approximately 60% of documented cases. Most published ONM cases (n = 41) were treated with carbamazepine, demonstrating a success rate of 87.8%. Of the published cases, cranial nerve III was involved 56% of the time, cranial nerve VI was affected in 39% of cases, and only 9% of ONM cases invo...Continue Reading


Jun 1, 1979·Annals of Neurology·J W LanceJ Pollard
Jul 1, 1986·Archives of Ophthalmology·W T ShultsJ J Corbett
Dec 15, 1986·American Journal of Ophthalmology·S LessellJ F Rizzo
Jan 1, 1987·Archives of Ophthalmology·J S Elston
Jan 1, 1972·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·W Papst
May 1, 1983·Journal of Neurology, Neurosurgery, and Psychiatry·D E Bateman, M Saunders
Nov 1, 1993·Survey of Ophthalmology·S A Newman
Jan 1, 1996·Neurology·M J MorrowA C Arnold
Apr 1, 1996·The British Journal of Ophthalmology·E EzraG T Plant
Mar 1, 1997·Archives of Ophthalmology·S M ChungO A Cruz
Jul 1, 1997·American Journal of Ophthalmology·A R Harrison, J D Wirtschafter
Oct 24, 1997·Archives of Ophthalmology·C L Haupert, N J Newman
Jul 13, 1999·Strabismus·A Bacskulin, R Guthoff
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K J Smith, W I McDonald
Oct 14, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·C TiliketeA Vighetto
Apr 3, 2002·Neurochemical Research·António F AmbrósioArsélio P Carvalho
Sep 11, 2002·Strabismus·Julia FrickeWalter Rüssmann
Apr 15, 2003·Clinical Neurology and Neurosurgery·Betigül Yürüten, Süleyman Ilhan
Jan 1, 1962·Archives of Ophthalmology·R J JOHNSH J RENKEN
Jan 1, 2004·American Journal of Ophthalmology·Neil R Miller, Andrew G Lee
Jan 12, 2005·Archives of Ophthalmology·Michelle C BanksSimmons Lessell
Feb 25, 2005·Journal of Neurology·Maurizio VersinoVittorio Cosi
Mar 23, 2006·Klinische Monatsblätter für Augenheilkunde·G Koop, M Gräf
Apr 26, 2006·Neurology·E Brannon MorrisMary Ellen Hoehn
May 24, 2006·Neurology·Maud JacobCaroline Tilikete
Jul 18, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Paul Maddison
Aug 2, 2006·The British Journal of Psychiatry : the Journal of Mental Science·U D ParthasarathiP C Fletcher
Jan 6, 2007·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Akihiko Oohira, Tatsuyuki Furuya
Jan 6, 2007·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Kwang-Dong ChoiJi Soo Kim
Sep 1, 2007·Strabismus·Noa Ela-DalmanJoseph L Lasky
Apr 2, 2008·Journal of the Neurological Sciences·Hee Young ParkJi Soo Kim
Jul 9, 2008·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M van WaverenD Besch
Aug 19, 2008·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Alexandre de Saint SardosLuis H Ospina
Nov 14, 2008·Archivos de la Sociedad Española de Oftalmología·V M Asensio-SánchezI Rodríguez-Vaca
Jun 6, 2009·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Jason W MuchSteven A Newman
Aug 21, 2010·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Hui-Chuan Kau, Chieh-Chih Tsai
Oct 7, 2010·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Daniel J Salchow, Thomas K Wermund
Sep 29, 2011·Journal of Neurology, Neurosurgery, and Psychiatry·Robert FeketeJoseph Jankovic

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