Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma

Oncotarget
Shengda CaoDapeng Lei

Abstract

Circular RNAs (circRNAs), a novel class of endogenous noncoding RNAs, have been shown to have important roles in a number of diseases, including several types of cancers. We hypothesized that circRNAs are involved in the pathogenesis of hypopharyngeal squamous cell carcinoma (HSCC). To test our hypothesis, we initially compared the expression profiles of circRNAs in 4 paired HSCC and adjacent normal tissue samples by using a circRNA microarray. The microarray data showed that 2392 circRNAs, including 1304 upregulated and 1088 downregulated circRNA transcripts, were significantly dysregulated in the HSCC tissues. The 10 most dysregulated circRNAs from the microarray analysis were further validated in another 32 pairs of specimens using quantitative real-time polymerase chain reaction assays. These circRNAs might sponge microRNAs (miRNAs) in predicted circRNA-miRNA-mRNA networks. Bioinformatics analysis was also performed to predict possible pathways in which these networks might be involved. Finally, we analyzed the interaction between validated circRNAs and their potential cancer-related miRNA targets. We are the first to comprehensively delineate the expression profiles of circRNAs in HSCC and to provide potential candidates f...Continue Reading

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Citations

Feb 9, 2018·Oncotarget·Zhijie XuZhicheng Gong
Mar 23, 2019·Molecular Cancer·Yang GuoLiang Zhou
Nov 4, 2017·Journal of Experimental & Clinical Cancer Research : CR·Yu ZhangWenrong Xu
Jun 20, 2018·Cancer Biomarkers : Section a of Disease Markers·Jian ZhouWeiwei Tang
Aug 2, 2018·Journal of Hematology & Oncology·Yiting GengChangping Wu
Nov 6, 2020·BioMed Research International·Danhui WangYongjun Wu
May 18, 2021·Frontiers in Oncology·Panchun LiZhaojian Gong

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Methods Mentioned

BETA
electrophoresis
Feature Extraction
PCR

Software Mentioned

SPSS
TargetScan
miRanda
Arraystar
Treeview
GraphPad Prism
GeneSpring
Cytoscape
KOBAS
GraphPad

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