Novel clinical and radiomic predictors of rapid disease progression phenotypes among lung cancer patients treated with immunotherapy: An early report

Lung Cancer : Journal of the International Association for the Study of Lung Cancer
Ilke TunaliMatthew B Schabath

Abstract

Immune-checkpoint blockades have exhibited durable responses and improved long-term survival in a subset of advanced non-small cell lung cancer (NSCLC) patients. However, highly predictive markers of positive and negative responses to immunotherapy are a significant unmet clinical need. The objective of this study was to identify clinical and computational image-based predictors of rapid disease progression phenotypes in NSCLC patients treated with immune-checkpoint blockades. Using time-to-progression (TTP) and/or tumor growth rates, rapid disease progression phenotypes were developed including hyperprogressive disease. The pre-treatment baseline predictors that were used to identify these phenotypes included patient demographics, clinical data, driver mutations, hematology data, and computational image-based features (radiomics) that were extracted from pre-treatment computed tomography scans. Synthetic Minority Oversampling Technique (SMOTE) was used to subsample minority groups to eliminate classification bias. Patient-level probabilities were calculated from the final clinical-radiomic models to subgroup patients by progression-free survival (PFS). Among 228 NSCLC patients treated with single agent or double agent immunoth...Continue Reading

References

Jan 20, 2012·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Philippe LambinHugo J W L Aerts
Jun 4, 2014·Nature Communications·Hugo J W L AertsPhilippe Lambin
Feb 20, 2015·Molecular Cancer Therapeutics·Sandip Pravin Patel, Razelle Kurzrock
Jun 2, 2015·The New England Journal of Medicine·Julie BrahmerDavid R Spigel
Sep 29, 2015·The New England Journal of Medicine·Hossein BorghaeiJulie R Brahmer
Nov 19, 2015·Radiology·Robert J GilliesHedvig Hricak
Mar 6, 2016·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Takehito Shukuya, David P Carbone
Aug 18, 2016·Journal for Immunotherapy of Cancer·Claud Grigg, Naiyer A Rizvi
Aug 28, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Kazuhiko ShienIgnacio I Wistuba
Oct 11, 2016·The New England Journal of Medicine·Martin ReckUNKNOWN KEYNOTE-024 Investigators
Nov 9, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stéphane ChampiatCharles Ferté
Jan 20, 2017·Nature·Daniel S Chen, Ira Mellman
Mar 14, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Stephen J BagleyCorey J Langer
Mar 30, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Shumei KatoRazelle Kurzrock
Apr 19, 2017·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Saâda-BouzidC Le Tourneau
Jun 11, 2017·Critical Reviews in Oncology/hematology·Zachary Z ReinsteinBenedito A Carneiro
Jul 22, 2017·ELife·Patrick GrossmannHugo Jwl Aerts
Apr 17, 2018·The New England Journal of Medicine·Leena GandhiUNKNOWN KEYNOTE-189 Investigators

❮ Previous
Next ❯

Citations

May 28, 2019·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E Deutsch, N Paragios
Jul 6, 2020·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·L Leon-MateosL Gorospe
May 13, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Maxime FrelautEdith Borcoman
Jul 14, 2020·World Journal of Gastroenterology : WJG·Stuart L PolkDaniel Jeong
May 26, 2020·Future Oncology·Elaine Johanna Limkin, Roger Sun
Apr 25, 2020·International Journal of Molecular Sciences·Florian HuemerRichard Greil
Oct 10, 2020·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Roberto García-FigueirasJoan C Vilanova
Nov 21, 2020·Expert Review of Anticancer Therapy·Chandra BortolottoAndrea Riccardo Filippi
Oct 29, 2020·Journal of Hepatology·Stephen L Chan
Jan 21, 2021·Cancers·Stefania AngelicolaArianna Palladini
Jan 2, 2021·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·B AbbarS Brosseau
Aug 1, 2020·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Jaryd R ChristieSarah A Mattonen
Dec 4, 2020·Methods : a Companion to Methods in Enzymology·Chong ZhangLeonard Wee
Jun 21, 2020·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Isabella Fornacon-WoodGareth J Price
Apr 14, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·J LiuX Xie
Jun 26, 2020·International Journal of Radiation Oncology, Biology, Physics·Robert R FlavellSue S Yom
May 4, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Federico CucchiaraMarzia Del Re
May 4, 2021·Clinical and Translational Radiation Oncology·Jarey H WangClifton David Fuller
Mar 27, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael A CannarileVaios Karanikas
Jan 13, 2021·Cold Spring Harbor Perspectives in Medicine·Ilke TunaliMatthew B Schabath

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.