Novel composite hyaluronan/type I collagen/fibrin scaffold enhances repair of osteochondral defect in rabbit knee

Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Eva FilovaE Amler

Abstract

A new composite scaffold containing type I collagen, hyaluronan, and fibrin was prepared with and without autologous chondrocytes and implanted into a rabbit femoral trochlea. The biophysical properties of the composite scaffold were similar to native cartilage. The macroscopic, histological, and immunohistochemical analysis of the regenerated tissue from cell-seeded scaffolds was performed 6 weeks after the implantation and predominantly showed formation of hyaline cartilage accompanied by production of glycosaminoglycans and type II collagen with minor fibro-cartilage production. Implanted scaffolds without cells healed predominantly as fibro-cartilage, although glycosaminoglycans and type II collagen, which form hyaline cartilage, were also observed. On the other hand, fibro-cartilage or fibrous tissue or both were only formed in the defects without scaffold. The new composite scaffold containing collagen type I, hyaluronan, and fibrin, seeded with autologous chondrocytes and implanted into rabbit femoral trochlea, was found to be highly effective in cartilage repair after only 6 weeks. The new composite scaffold can therefore enhance cartilage regeneration of osteochondral defects, by the supporting of the hyaline cartilage...Continue Reading

References

Mar 1, 1989·Analytical Biochemistry·J S LeederS P Spielberg
Oct 6, 1994·The New England Journal of Medicine·M BrittbergL Peterson
Aug 1, 1993·Acta Orthopaedica Scandinavica·G N HommingaW B van den Berg
May 1, 1996·The Journal of Bone and Joint Surgery. American Volume·E B Hunziker, L C Rosenberg
Oct 23, 1997·The Journal of Bone and Joint Surgery. British Volume·S R FrenkelJ M Pachence
Jun 13, 1998·Biotechnology Progress·G Vunjak-NovakovicL E Freed
Aug 28, 2001·Journal of Biomedical Materials Research·E J CatersonR S Tuan
Sep 22, 2001·American Journal of Surgery·M R Jackson
Jul 12, 2002·Microscopy Research and Technique·Stanisław MoskalewskiAnna Osiecka-Iwan
Jun 6, 2003·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Rhoda S NarinsStacy Smith
Aug 19, 2003·Biomaterials·Jeanie L Drury, David J Mooney
Dec 18, 2004·Biomaterials·Masanori KobayashiMasanori Oka
Dec 21, 2004·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Kenneth W NgClark T Hung
Sep 29, 2005·European Journal of Radiology·Stefan MarlovitsVilmos Vécsei
Oct 18, 2005·International Urogynecology Journal and Pelvic Floor Dysfunction·Sumana KoduriPeter K Sand
Jan 18, 2006·Tissue Engineering·Pieter J EmansRoel Kuijer
Feb 14, 2006·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Cheng-Hung ChouFeng-Huei Lin

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Citations

Jan 10, 2012·Journal of Materials Science. Materials in Medicine·Michala RampichováEvžen Amler
Jul 8, 2011·Injury·Javier Vaquero, Francisco Forriol
Oct 23, 2010·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Dan QuLin Cheng
Mar 19, 2013·International Journal of Pharmaceutics·Eva FilováEvžen Amler
Sep 11, 2016·Materials Science & Engineering. C, Materials for Biological Applications·Suren P UswattaAmbalangodage C Jayasuriya
Jun 22, 2016·Tissue Engineering. Part a·Amanda M MeppelinkMark A Randolph
May 16, 2014·World Journal of Orthopedics·Giuseppe MusumeciSergio Castorina
Oct 23, 2010·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Michala RampichováEvžen Amler
Mar 12, 2011·Biomedical Materials·Chiung L YangYng J Wang
May 18, 2016·Journal of Materials Science. Materials in Medicine·Kedong SongTianqing Liu
Jan 21, 2021·Tissue Engineering. Part B, Reviews·Konstantinos TheodoridisAristeidis Kritis
Sep 14, 2015·ACS Biomaterials Science & Engineering·C A VilelaR L Reis

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