Novel Conducting and Biodegradable Copolymers with Noncytotoxic Properties toward Embryonic Stem Cells

ACS Omega
Aruã C da SilvaSusana I Cordoba de Torresi

Abstract

Electroactive biomaterials that are easily processed as scaffolds with good biocompatibility for tissue regeneration are difficult to design. Herein, the synthesis and characterization of a variety of novel electroactive, biodegradable biomaterials based on poly(3,4-ethylenedioxythiphene) copolymerized with poly(d,l lactic acid) (PEDOT-co-PDLLA) are presented. These copolymers were obtained using (2,3-dihydrothieno[3,4-b][1,4]dioxin-2-yl)methanol (EDOT-OH) as an initiator in a lactide ring-opening polymerization reaction, resulting in EDOT-PDLLA macromonomer. Conducting PEDOT-co-PDLLA copolymers (in three different proportions) were achieved by chemical copolymerization with 3,4-ethylenedioxythiophene (EDOT) monomers and persulfate oxidant. The PEDOT-co-PDLLA copolymers were structurally characterized by 1H NMR and Fourier transform infrared spectroscopy. Cyclic voltammetry confirmed the electroactive character of the materials, and conductivity measurements were performed via electrochemical impedance spectroscopy. In vitro biodegradability was evaluated using proteinase K over 35 days, showing 29-46% (w/w) biodegradation. Noncytotoxicity was assessed by adhesion, migration, and proliferation assays using embryonic stem cells ...Continue Reading

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Citations

Mar 27, 2020·Polymers·Nabasmita Maity, Arnab Dawn
May 4, 2021·Macromolecular Rapid Communications·Antonio Dominguez-AlfaroDavid Mecerreyes
Jan 31, 2020·ACS Applied Materials & Interfaces·Emin IstifEleni Pavlopoulou

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Methods Mentioned

BETA
biosensing
nuclear magnetic resonance
optical
flow cytometry

Software Mentioned

ORCA
StrataQuest
NOVA
ImageJ

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