Novel Cross-Border Approaches to Optimise Identification of Asymptomatic and Artemisinin-Resistant Plasmodium Infection in Mobile Populations Crossing Cambodian Borders.

PloS One
Hannah M EdwardsArantxa Roca-Feltrer

Abstract

Human population movement across country borders presents a real challenge for malaria control and elimination efforts in Cambodia and its neighbouring countries. To quantify Plasmodium infection among the border-crossing population, including asymptomatic and artemisinin resistant (AR) parasites, three official border crossing points, one from each of Cambodia's borders with Thailand, Laos and Vietnam, were selected for sampling. A total of 3206 participants (of 4110 approached) were recruited as they crossed the border, tested for malaria and interviewed. By real-time polymerase chain reaction (RT-PCR), 5.4% of all screened individuals were found to harbour Plasmodium parasites. The proportion was highest at the Laos border (11.5%). Overall there were 97 P. vivax (55.7%), 55 P. falciparum (31.6%), two P. malariae (1.1%) and 20 mixed infections (11.5%). Of identified infections, only 20% were febrile at the time of screening. Of the 24 P. falciparum samples where a further PCR was possible to assess AR, 15 (62.5%) had mutations in the K13 propeller domain gene, all from participants at the Laos border point. Malaria rapid diagnostic test (RDT) pLDH/HRP-2 identified a positivity rate of 3.2% overall and sensitivity compared to ...Continue Reading

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Citations

Aug 28, 2016·Malaria Journal·Valérie BriandNadine Fievet
Sep 10, 2017·Malaria Journal·Natalia Tejedor-GaravitoSimon Kunene
Jan 24, 2018·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Gabriele RossiJean-Marie Kindermans
May 29, 2021·BMC Medicine·Katherine O'FlahertyFreya J I Fowkes
Aug 6, 2021·Expert Review of Anti-infective Therapy·Charlotte RasmussenPascal Ringwald

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Methods Mentioned

BETA
PCR

Software Mentioned

Stata

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