PMID: 8959245Dec 10, 1996Paper

Novel, cross-restricted, conserved, and immunodominant cytotoxic T lymphocyte epitopes in slow progressors in HIV type 1 infection

AIDS Research and Human Retroviruses
Philip J R GoulderA J McMichael

Abstract

HIV-specific cytotoxic T lymphocytes (CTLs) play an important role in the immune response to HIV infection. Long-term nonprogressors (LTNPs) or slow progressors (SPs) in HIV infection may make qualitatively different CTL responses compared to those generated by seropositive individuals who progress to disease at a faster rate. The class I molecule HLA-B*57 has been identified as one restriction element overrepresented in SP groups studied, and, together with the closely related molecule HLA-B*58, occurs commonly in ethnic groups where HIV is most prevalent. In this study, we have identified five new HLA-B*57-restricted CTL epitopes recognized by SP donors, one of which is also HLA-B*5801 restricted. These HLA-B*57-restricted responses represent the dominant HIV-specific CTL response in each of the SP donors tested. These and other such epitopes may be an important component in future vaccine design.

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Citations

Aug 11, 2005·Current HIV/AIDS Reports·Stephen A MiguelesMark Connors
Sep 14, 2002·Current Infectious Disease Reports·Stephen A. Migueles, Mark Connors
Mar 24, 2004·Trends in Immunology·Otto O Yang
Apr 28, 2004·Microbes and Infection·Kathleen L Collins
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Jun 27, 2003·Human Immunology·Sunita S Balla-JhagjhoorsinghJonathan L Heeney
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Aug 3, 2004·Nature Reviews. Immunology·Philip J R Goulder, David I Watkins
Jul 12, 2008·Nature Reviews. Immunology·Philip J R Goulder, David I Watkins
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Dec 13, 2005·Sexual Health·Miranda Z Smith, Stephen J Kent
Jan 10, 2001·The Journal of Experimental Medicine·P J GoulderC Brander
Apr 7, 2004·The Journal of Experimental Medicine·Rika DraenertPhilip J R Goulder
Mar 23, 2005·The Journal of Experimental Medicine·Alasdair LesliePhilip Goulder
Mar 6, 2004·AIDS Research and Human Retroviruses·Jianming TangUNKNOWN Zambia-UAB HIV Research Project
Oct 16, 2012·AIDS Research and Human Retroviruses·Jairam R LingappaUNKNOWN Partners in Prevention HSV/HIV Transmission Study Team
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Jul 20, 2012·Journal of Virology·Catherine A BrennanBeth D Jamieson
Jul 4, 2008·Journal of Virology·Philippa C MatthewsPhilip J R Goulder

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