Novel cynomolgus macaque MHC-DPB1 polymorphisms in three South-East Asian populations

Tissue Antigens
K SanoH Inoko

Abstract

Cynomolgus macaques (Macaca fascicularis, Mafa), alias the crab-eating monkeys or long-tailed macaques, live across a vast range of South-East Asia. These non-human primates have emerged as important animal models in infectious and chronic diseases and transplantation studies, necessitating a more extensive characterization of their major histocompatibility complex polymorphic regions. The current information on the polymorphic variation or diversity of the Mafa-DPB1 locus is largely limited in comparison with the more commonly studied rhesus macaque DPB1 locus. In this article, to better elucidate the degree and types of polymorphisms and genetic differences of Mafa-DPB1 locus among three South-East Asian populations and to investigate how the allele differences between macaques and humans might affect their respective immune responses, we identified 40 alleles within exon 2 of the Mafa-DPB1 locus by DNA sequencing using 217 individuals. We also performed evolutionary and population analyses using these sequences to reveal some population-specific alleles and trans-species allelic conservation between the cynomolgus macaques and the rhesus macaques. Of the 40 new alleles, eight belong to a newly identified lineage group not pr...Continue Reading

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Citations

Mar 27, 2007·Immunogenetics·Shelby L O'ConnorDavid H O'Connor
Dec 25, 2008·Immunogenetics·Kevin J CampbellDavid H O'Connor
Jun 23, 2010·Yi chuan = Hereditas·Huai-Liang XuXiao-Yue Chen
Dec 5, 2012·Yi chuan = Hereditas·Jia-Yi LiHuai-Liang Xu
Jan 23, 2010·Immunogenetics·Alice AarninkAntoine Blancher
Sep 2, 2011·Immunogenetics·Yusuke SaitoAkinori Kimura
Apr 28, 2012·American Journal of Primatology·Aixue LiYansheng Shi
Nov 28, 2018·Inflammation and Regeneration·Hirohito IshigakiKazumasa Ogasawara
Aug 29, 2019·Cells·Takashi Shiina, Antoine Blancher
Jan 28, 2022·Immunogenetics·Natasja G de GrootRonald E Bontrop

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