Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin dose

Clinical Pharmacology and Therapeutics
Feng ZhaoSoo Chin Lee

Abstract

Commonly occurring genetic variants in CYP2C9 are known to reduce catalytic activity and are associated with enhanced patient sensitivity to warfarin. Interethnic differences in warfarin dose requirement have been described in the Asian population, and we postulate that this could be related to genetic variants of CYP2C9 that are unique to ethnic groups. We prospectively genotyped 125 patients who were receiving a stable daily warfarin dose to maintain international normalized ratio values between 2 and 3 through comprehensive sequencing of the promoter and coding regions of the CYP2C9 gene. The mean weight-adjusted warfarin maintenance dose was significantly lower for Malay and Chinese subjects than Indian subjects ( P <.001 and.014, respectively). Warfarin dose negatively correlated with age (r = -0.4, P <.001) but not with sex. Multiple variants were detected in the promoter, exonic, intronic, and 3'-untranslated regions of CYP2C9, of which 16 were novel, including 7 nonsynonymous exonic variants ( 208G>C, 374G>A, 485C>A, 895A>G, 1144C>T, 1190A>C, and 1362G>C ). CYP2C9*3, but not CYP2C9*2, was found in Chinese and Malay patients, and carriers of the CYP2C9*3 variant in Chinese ( P <.01) and Indian ( P <.01) patients, but not...Continue Reading

Citations

Feb 1, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Danxin WangJulie A Johnson
Oct 27, 2009·The Journal of Pharmacology and Experimental Therapeutics·Amarjit S ChaudhryErin G Schuetz
Nov 19, 2010·Drug Metabolism and Pharmacokinetics·Onkar SinghBalram Chowbay
May 14, 2010·Future Cardiology·Richard L SeipGualberto Ruaño
Dec 5, 2009·Pharmacogenomics·M T Michael LeeYuan-Tsong Chen
Apr 21, 2010·Pharmacogenomics·Guang-Ming TanBryan P Yan
Sep 27, 2008·Pakistan Journal of Biological Sciences : PJBS·S SadraiF Sadeghian
Jun 12, 2013·The Pharmacogenomics Journal·Y NiinumaM Hiratsuka
Aug 9, 2012·Future Cardiology·Larisa H Cavallari, Minoli A Perera
Jun 24, 2014·Pharmacogenomics·Yee Ming LeeLarisa H Cavallari
Mar 5, 2014·Expert Opinion on Drug Metabolism & Toxicology·Collet DandaraCollen Masimirembwa
Jun 12, 2009·Drug Metabolism Reviews·Shu-Feng ZhouBalram Chowbay
Aug 22, 2014·Drug Development and Industrial Pharmacy·Li WangGuo-Xin Hu
Jul 26, 2006·Expert Opinion on Drug Metabolism & Toxicology·Ann K Daly, Barry P King
May 17, 2006·Basic & Clinical Pharmacology & Toxicology·Claire Larramendy-GozaloLaurent Becquemont
Jun 2, 2007·Progress in Cardiovascular Nursing·Steven R Kayser
May 26, 2006·British Journal of Clinical Pharmacology·Farhad Kamali, Munir Pirmohamed
Nov 13, 2007·British Journal of Clinical Pharmacology·Suman LalBalram Chowbay
Oct 9, 2015·Research in Cardiovascular Medicine·Avisa TabibBehzad Poopak
Aug 25, 2016·Therapeutic Advances in Cardiovascular Disease·Rohan Shah, Manesh R Patel
Dec 18, 2007·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Yoshinari MorimotoKazuo Minematsu
Jan 18, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Herng-Der ChernChun-Wen Cheng
Sep 12, 2009·Drug Metabolism and Pharmacokinetics·Edwin SandanarajBalram Chowbay
Apr 26, 2014·Stroke; a Journal of Cerebral Circulation·Ka Sing Lawrence WongUNKNOWN Executive Steering Committee and the ROCKET AF Study Investigators
Aug 5, 2006·Current Opinion in Hematology·Farhad Kamali
Jan 10, 2008·Clinical Pharmacology and Therapeutics·M-S WenY-T Chen
Nov 26, 2008·European Journal of Clinical Pharmacology·Jonatan D LindhAnders Rane
Jan 14, 2009·American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists·Michael P GulsethWilliam E Dager
Nov 27, 2009·Journal of Pharmacokinetics and Pharmacodynamics·Eunice YuenLeon Aarons
Jan 5, 2010·The Korean journal of laboratory medicine·Min-Jung KwonSoo-Youn Lee
Jun 22, 2006·Pharmacogenetics and Genomics·Keiko MaekawaJun-ichi Sawada
Apr 17, 2010·Journal of Thrombosis and Thrombolysis·Sei Keng KohLai Heng Lee
Aug 12, 2005·European Journal of Clinical Pharmacology·Xiumei HongXiping Xu

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