Novel delivery device for monolithical solid oral dosage forms for personalized medicine

International Journal of Pharmaceutics
Klaus Wening, Jörg Breitkreutz

Abstract

There is an evident need for solid oral dosage forms allowing patients' tailor-made dosing due to variations in metabolization or small therapeutic indexes of drug substances. The objective of this work is the development of a device equipped with a novel solid dosage form, containing carvedilol as model drug, for the delivery of monolithical drug carriers in individual doses. The device was developed and constructed enabling an exact feed rate and dose adjustment by a cutting mechanism. A twin-screw extruder was used for producing cylindrical solid dosage forms. Divided doses were characterized by mass variation, cutting behavior and drug dissolution in order to investigate their applicability for practical use. Different formulations could be extruded obtaining straight cylindrical rods, which are divisible in exact slices by using the novel device. Forces below 20 N were needed to divide doses which comply with pharmacopoeial specification "conformity of mass". The developed formulations exhibit a sustained release of carvedilol within a range from 7 up to 16 h. A novel system consisting of a device and a cylindrical dosage form was developed. Patients' individual doses can be applied as monolithical solid dosage forms for o...Continue Reading

References

Dec 1, 1992·Trends in Pharmacological Sciences·S CholertonJ R Idle
Oct 26, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E I KelebJ P Remon
Mar 7, 2002·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·E van SantenH W Frijlink
Apr 3, 2002·Journal of the American Pharmaceutical Association : APhA·Jaja TengJames E Polli
Apr 3, 2002·Journal of the American Pharmaceutical Association : APhA·Jack M RosenbergFotios Plakogiannis
Jul 25, 2003·International Journal of Pharmaceutics·Susanne BredenbergChrister Nyström
Sep 19, 2003·The New England Journal of Medicine·Gregory L KearnsRalph E Kauffman
Feb 6, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Helton SantosJoão José Sousa
Feb 6, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Nienke RodenhuisDirk M Barends
Dec 9, 2004·Journal of Clinical Pharmacy and Therapeutics·D BrownP H Rowe
Jun 28, 2005·International Journal of Pharmaceutics·Joseph F Standing, Catherine Tuleu
Oct 7, 2006·European Journal of Clinical Pharmacology·R QuinzlerW E Haefeli
Nov 13, 2007·British Journal of Clinical Pharmacology·Stefanie AlbersStephanie Läer
Nov 16, 2007·Pharmacology & Therapeutics·Magnus Ingelman-SundbergCristina Rodriguez-Antona
Oct 16, 2008·Current Drug Metabolism·Shu-Feng ZhouWei Duan
Jan 28, 2009·Pediatrics·Sarah A ThomsonAlastair G Sutcliffe

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Citations

Dec 14, 2011·AAPS PharmSciTech·Christian Muehlenfeld, Markus Thommes
Sep 10, 2014·International Journal of Pharmaceutics·Eva Julia LaukampJoerg Breitkreutz
Jul 15, 2015·Expert Opinion on Drug Delivery·Felipe L LopezMine Orlu Gul
Aug 19, 2015·Journal of Pharmaceutical Sciences·Jukka Rantanen, Johannes Khinast
Jan 13, 2016·International Journal of Pharmaceutics·Eva Julia LaukampJoerg Breitkreutz
Feb 22, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Randall J Mrsny
Feb 11, 2015·International Journal of Pharmaceutics·Johanna AhoJukka Rantanen
Jul 4, 2012·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Buket AksuMarco Weimer
Nov 13, 2010·International Journal of Pharmaceutics·Klaus Wening, Jörg Breitkreutz
Jan 4, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Eva Julia LaukampJoerg Breitkreutz
Jan 1, 2012·Journal of Personalized Medicine·Klaus WeningJörg Breitkreutz
Apr 15, 2015·European Journal of Clinical Pharmacology·Juan TamargoPhillipe Mabo
Apr 18, 2018·Pharmaceutics·Jens WesholowskiMarkus Thommes

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