Novel depots of buprenorphine have a long-acting effect for the management of physical dependence to morphine

The Journal of Pharmacy and Pharmacology
Kuo-Sheng LiuJhi-Joung Wang

Abstract

Buprenorphine is a promising new pharmacotherapy for the management of physical dependence to opioids. The aim of the study was to evaluate the duration of action of several novel depots of buprenorphine in the treatment of physical dependence to morphine in mice. Following intramuscular injection, the duration of action of several novel oil-based depots of buprenorphine base in morphine-dependent mice were evaluated. The traditional dosage form of buprenorphine hydrochloride in saline was used as control. We found that the depot of buprenorphine base in sesame oil produced a dose-related long-lasting effect. On an equimolar basis of 6 micromol kg(-1), its effect was 5.7-fold longer than that of buprenorphine hydrochloride in saline. When prepared in several other oleaginous vehicles (castor oil, cottonseed oil, peanut oil and soybean oil), buprenorphine base also produced a long-lasting effect, which was similar to buprenorphine base in sesame oil. In conclusion, buprenorphine base, when prepared in oleaginous vehicles and injected intramuscularly in mice, produced a long-lasting effect on physical dependence to morphine.

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Citations

Sep 23, 2008·Current Psychiatry Reports·Iván D Montoya, Frank Vocci
Oct 20, 2012·Lab Animal·Michael GuarnieriPatricia Zadnik
Feb 7, 2013·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Su-Zhen WuChin-Chen Chu
Oct 24, 2007·Peptides·Richard J Bodnar
Jun 24, 2011·Journal of Veterinary Pharmacology and Therapeutics·Q ShangC Berkland
Mar 30, 2017·Therapeutic Advances in Psychopharmacology·Preeti BarnwalArunava Saha
Oct 23, 2020·Current Medical Research and Opinion·Michael GuarnieriBetty Tyler

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