Novel description of the large conductance Ca2+ -modulated K+ channel current, BK, during an action potential from suprachiasmatic nucleus neurons

Physiological Reports
John R Clay

Abstract

The contribution of the large conductance, Ca2+-modulated, voltage-gated K+ channel current, IBK, to the total current during an action potential (AP) from suprachiasmatic nucleus (SCN) neurons is described using a novel computational approach. An experimental recording of an SCN AP and the corresponding AP-clamp recording of IBK from the literature were both digitized. The AP data set was applied computationally to a kinetic model of IBK that was based on results from a clone of the BK channel α subunit heterologolously expressed in Xenopus oocytes. The IBK model result during an AP was compared with the AP-clamp recording of IBK The comparison suggests that a change in the intracellular Ca2+ concentration does not have an immediate effect on BK channel kinetics. Rather, a delay of a few milliseconds may occur prior to the full effect of a change in Cai2+ As shown elsewhere, the β2 subunit of the BK channel in the SCN, which is present in the daytime along with the α subunit, shifts the BK channel activation curve leftward on the voltage axis relative to the activation curve of BK channels comprised of the α subunit alone. That shift may underlie the diurnal changes in electrical activity that occur in the SCN and it may also ...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S T Inouye, H Kawamura
Oct 1, 1992·Journal of Neurophysiology·D A McCormick, J R Huguenard
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·R LlinásS M Simon
Dec 1, 1994·The Journal of Membrane Biology·H Parnas, I Parnas
Aug 15, 1998·Journal of Neurophysiology·J R Clay
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·M WallnerL Toro
Feb 28, 1956·The Journal of Physiology·B FRANKENHAEUSER, A L HODGKIN
Oct 15, 2003·Neuron·George J AugustineKeiko Tanaka
Sep 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alexander C JacksonBruce P Bean
Jan 18, 2005·Journal of Neurophysiology·Liston K Purvis, Robert J Butera
Jul 18, 2006·Nature Neuroscience·Andrea L MeredithRichard W Aldrich
Jul 28, 2006·Nature Neuroscience·Christopher S Colwell
May 22, 2007·Nature Reviews. Neuroscience·Bruce P Bean
Sep 27, 2008·Neuron·Bernd Fakler, John P Adelman
Oct 10, 2009·Science·Mino D C BelleHugh D Piggins
Nov 1, 2012·Proceedings of the National Academy of Sciences of the United States of America·Jenna R Montgomery, Andrea L Meredith
Nov 24, 2012·American Journal of Physiology. Cell Physiology·Jenna R MontgomeryAndrea L Meredith
Aug 31, 2013·PLoS Computational Biology·Casey O DiekmanDaniel B Forger
Nov 28, 2013·The Journal of General Physiology·Chris ShelleyAndrea L Meredith
Mar 5, 2016·Nature Communications·Joshua P WhittAndrea L Meredith

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Feb 12, 2019·Annual Review of Physiology·Vivian Gonzalez-Perez, Christopher J Lingle

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