Novel detection schemes of nuclear magnetic resonance and magnetic resonance imaging: applications from analytical chemistry to molecular sensors

Annual Review of Analytical Chemistry
Elad HarelShoujun Xu

Abstract

Nuclear magnetic resonance (NMR) is a well-established analytical technique in chemistry. The ability to precisely control the nuclear spin interactions that give rise to the NMR phenomenon has led to revolutionary advances in fields as diverse as protein structure determination and medical diagnosis. Here, we discuss methods for increasing the sensitivity of magnetic resonance experiments, moving away from the paradigm of traditional NMR by separating the encoding and detection steps of the experiment. This added flexibility allows for diverse applications ranging from lab-on-a-chip flow imaging and biological sensors to optical detection of magnetic resonance imaging at low magnetic fields. We aim to compare and discuss various approaches for a host of problems in material science, biology, and physics that differ from the high-field methods routinely used in analytical chemistry and medical imaging.

References

Jan 1, 1985·Magnetic Resonance Imaging·K M LüdekeR Tischler
Jun 4, 1971·Biochemical and Biophysical Research Communications·E Oldfield, D Chapman
Aug 1, 1993·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A Macovski, S Conolly
Jan 1, 1996·Annual Review of Biophysics and Biomolecular Structure·R G Bryant
May 8, 1998·Journal of Magnetic Resonance·D M GregoryR E Botto
Jun 6, 1998·Science·M U KoppA Manz
May 19, 1986·Physical Review Letters·D W Schaefer, K D Keefer
Nov 7, 2000·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K M Ward, R S Balaban
Jul 18, 2001·Journal of the American Chemical Society·S ZhangA D Sherry
Aug 30, 2001·Journal of the American Chemical Society·N GoffeneyP C van Zijl
Sep 6, 2001·Proceedings of the National Academy of Sciences of the United States of America·M M SpenceP G Schultz
Jan 26, 2002·Science·Abraham D StroockGeorge M Whitesides
Mar 23, 2002·Science·Robert McDermottJohn Clarke
Sep 13, 2002·Physical Review Letters·J C AllredM V Romalis
Nov 16, 2002·Angewandte Chemie·Silvio AimeEnzo Terreno
Feb 21, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Peter C M van ZijlSusumu Mori
Mar 12, 2003·Genes & Development·Tarik F Massoud, Sanjiv S Gambhir
Apr 11, 2003·Nature·I K KominisM V Romalis
May 28, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Karim SnoussiPeter C M van Zijl
Jul 24, 2003·Proceedings of the National Academy of Sciences of the United States of America·Adam J MouléAlexander Pines
Oct 22, 2003·Accounts of Chemical Research·Shanrong ZhangA Dean Sherry
Dec 4, 2003·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinyuan ZhouPeter C M van Zijl
Jan 17, 2004·Magnetic Resonance Imaging·Thomas J LoweryDavid E Wemmer
Mar 17, 2004·Nature Biotechnology·Jong Wook HongStephen R Quake
Mar 26, 2004·Journal of Magnetic Resonance·Juliette A SeeleyAlexander Pines
May 4, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jinyuan ZhouPeter C M Van Zijl
Nov 5, 2004·Physical Review Letters·V V YashchukA Pines
Nov 19, 2004·Journal of the American Chemical Society·Megan M SpenceAlexander Pines
Feb 4, 2005·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Seung Kyun LeeJohn Clarke
Feb 22, 2005·Angewandte Chemie·Silvio AimeEnzo Terreno
Feb 24, 2005·Lab on a Chip·Henk WensinkAlbert van den Berg
May 17, 2005·Journal of Magnetic Resonance·Phillip Zhe SunJinyuan Zhou
May 21, 2005·Physical Review Letters·I M Savukov, M V Romalis
Aug 11, 2005·Physical Review Letters·Stephan AppeltBernhard Blümich
Aug 11, 2005·Physical Review Letters·I M SavukovK L Sauer
Oct 4, 2005·Physical Review Letters·J GranwehrY-Q Song
Oct 11, 2005·Proceedings of the National Academy of Sciences of the United States of America·Christian HiltyAlexander Pines
Oct 22, 2005·Journal of Magnetic Resonance·K EhrmannR S Popovic
Nov 29, 2005·Journal of Magnetic Resonance·Michael MössleJohn Clarke
Nov 29, 2005·Angewandte Chemie·Christian HiltyAlexander Pines
Dec 13, 2005·Chembiochem : a European Journal of Chemical Biology·Thomas J LoweryDavid E Wemmer

❮ Previous
Next ❯

Citations

Mar 12, 2011·Annual Review of Analytical Chemistry·Raluca M Fratila, Aldrik H Velders
Oct 30, 2012·Progress in Nuclear Magnetic Resonance Spectroscopy·Richard A GreenGary G R Green
Oct 28, 2015·Trends in Biotechnology·Seung Min Yoo, Sang Yup Lee
Nov 17, 2009·Current Opinion in Chemical Biology·Olena Taratula, Ivan J Dmochowski
Jan 29, 2014·Contrast Media & Molecular Imaging·Jörg DöpfertLeif Schröder
May 23, 2015·Journal of Magnetic Resonance·J MitchellA Clarke
Oct 16, 2016·Magnetic Resonance Imaging Clinics of North America·Travis C SalzilloPratip K Bhattacharya
May 23, 2014·Nature Communications·Ricardo Jiménez-MartínezJohn Kitching
Oct 7, 2016·Chemistry : a European Journal·Danila A BarskiyEduard Y Chekmenev
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Jabadurai Jayapaul, Leif Schröder

❮ Previous
Next ❯

Methods Mentioned

BETA
nuclear magnetic resonance
NMR
chip
chips
chemical exchange saturation transfer
chemical exchange
biosensor
Chemical
biosensors
atomic

Software Mentioned

PARACEST
CEST
DIACEST
HYPER

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Adam J MouléAlexander Pines
Proceedings of the National Academy of Sciences of the United States of America
Jan H Ardenkjaer-LarsenKlaes Golman
© 2021 Meta ULC. All rights reserved