Novel dihydropyrazole-chromen: Design and modulates hTERT inhibition proliferation of MGC-803

European Journal of Medicinal Chemistry
Yan Yan ChenXin-Hua Liu

Abstract

Dominant-negative mutant of telomerase hTERT was demonstrated to show selective anticancer effects in tumor cells. But, an effective hTERT inhibitor with high selectivity has not been developed so far. Focused on hTERT, a novel dihydropyrazole-chromen (13k) controlling hTERT was designed. Title compound 13k occupied high antiproliferative activity against MGC-803 cells with IC50 value 1.41 μM, but it manifested obvious un-toxic effect on human normal gastric mucosa cells with the IC50 2.3 mM. Treated with compound 13k, the further inhibition mechanisms by modulating hTERT was explored, the results showed that expression of hTERT was clearly modulated, and then β-catenin activation was decreased, thereby the expression of downstream signaling molecules including c-myc and cyclin D1 was modulated, leading to inhibition MGC-803 cells proliferation.

Citations

Aug 25, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Xing ChenXin-Hua Liu
Oct 5, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Guo-Liang QiuWen-Jian Tang
May 12, 2020·Medicinal Research Reviews·Shalini BajajY C Mayur
Aug 6, 2020·International Journal of Molecular Sciences·Dimitris Matiadis, Marina Sagnou

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