Novel Drosophila model for psychiatric disorders including autism spectrum disorder by targeting of ATP-binding cassette protein A

Experimental Neurology
Ibuki UeokaMasamitsu Yamaguchi

Abstract

Autism spectrum disorder (ASD) is characterized by persistent deficits in social communication and social interactions, as well as restricted, stereotyped patterns of behavior and interests. In addition, alterations in circadian sleep-wake rhythm are common in young children with ASD. Mutations in ATP binding cassette subfamily A member 13 (ABCA13) have been recently identified in a monkey that displays behavior associated with ASD. ABCA13, a member of the ABCA family of proteins, is predicted to transport lipid molecules and is expressed in the human trachea, testis, bone marrow, hippocampus, cortex, and other tissues. However, its physiological function remains unknown. Drosophila CG1718 shows high homology to human ABCA genes including ABCA13 and is thus designated as Drosophila ABCA (dABCA). To elucidate the physiological role of dABCA, we specifically knocked down dABCA in all neurons of flies and investigated their phenotypes. The pan-neuron-specific knockdown of dABCA resulted in increased social space with the closest neighbor in adult male flies but exerted no effect on their climbing ability, indicating that the increase in social space is not due to a defect in their climbing ability. An activity assay with adult mal...Continue Reading

Citations

Nov 18, 2018·The Journal of Heredity·Rahul V RaneJohn G Oakeshott
Jan 4, 2018·G3 : Genes - Genomes - Genetics·Clarissa S SantosoKimberly McCall
Sep 12, 2018·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Shuji IritaniNorio Ozaki
Aug 24, 2019·International Journal of Molecular Sciences·Ibuki UeokaMasamitsu Yamaguchi
Dec 10, 2020·The Journal of Biological Chemistry·Mitsuhiro NakatoKazumitsu Ueda
Jan 23, 2021·The Journal of Biological Chemistry·Mitsuhiro NakatoKazumitsu Ueda

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