Novel drug delivery systems for ocular therapy: With special reference to liposomal ocular delivery

European Journal of Ophthalmology
Arpita BhattacharjeeBhaskar Mazumder

Abstract

Delivery of drugs to eyes is a great challenge to researchers because of a number of barriers in the eye preventing the actual dose from reaching the site. A number of ophthalmic delivery systems have been developed in the past couple of years that are not only new but also safe and reliable and help to overcome all those barriers in the eye which are responsible for the very less bioavailability of drugs. In this review, we tried to focus on current research in ocular delivery of drug substances giving special emphasis to liposomal delivery system. A brief analysis of other novel ocular delivery systems, ocular physiology, and microbial sources of disease are also highlighted herein. We analyzed the various research findings for churning a general idea for novel ocular delivery system and its future use. The novel formulations may overcome the addressed problems of ophthalmic medication and comply with the quality assurance issues. The liposomal delivery is advantageous as they have the ability to entrap both hydrophobic and hydrophilic drugs and are suitable for delivery to both the anterior and posterior segment of the eye. Therefore, the use of this alternative approach is quite a necessity.

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Citations

Dec 31, 2019·Recent Patents on Drug Delivery & Formulation·Zufika QamarSanjula Baboota
Jan 28, 2020·Recent Patents on Drug Delivery & Formulation·Anmol DograJasjeet Kaur Narang
May 10, 2020·Ophthalmology and Therapy·Alejandra Meza-RiosArturo Santos
Dec 2, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Julio C CugginoCecilia I Alvarez Igarzabal
Jan 9, 2021·Expert Opinion on Drug Delivery·José Javier López-CanoIrene Teresa Molina-Martínez
Feb 21, 2021·International Journal of Pharmaceutics·Ayat AllamNermin E Eleraky
Apr 30, 2021·Carbohydrate Polymers·Xiaodan ZhangQiang Zhu
Aug 18, 2021·International Journal of Pharmaceutics·Katarzyna B WróblewskaIzabela Muszalska-Kolos

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light scattering

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