Novel Drugs and Combination Therapies for the Treatment of Metastatic Melanoma

Journal of Clinical Medicine Research
Adarsh VennepureddyTerenig Terjanian

Abstract

Metastatic melanoma (MM) still remains as one of the most worrisome cancer known to mankind. In last two decades, treatment of melanoma took a dramatic turn with the discovery of targeted therapy which targets the mutations in mitogen-activated protein kinase (MAPK) pathway and immune checkpoint inhibitors. These new findings have led to emergence of many novel drugs that have been approved by FDA. Targeted therapy drugs such as vemurafenib, trametinib and dabrafenib target the MAPK pathway whereas immunotherapies such as ipilimumab, nivolumab and pembrolizumab block immune checkpoint receptors on T lymphocytes. All these drugs have shown to improve the overall survival in MM. Despite these recent discoveries, treatment of MM remains challenging because of rapid development of resistance to targeted therapy. This review will discuss recently approved drugs and their adverse effects and also shed light on combination therapy in treatment of melanoma.

Citations

Jun 22, 2016·Expert Opinion on Drug Discovery·Alex Kim, Mark S Cohen
Jul 18, 2016·Neuroimaging Clinics of North America·Asim F ChoudhriPaul Klimo
Aug 16, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Madelé van DykAndrew Rowland
Sep 3, 2016·World Journal of Surgical Oncology·Marta Troya-CastillaFrancisco Javier Márquez-Rivas
Oct 16, 2016·Magnetic Resonance Imaging Clinics of North America·Asim F ChoudhriPaul Klimo
Jul 28, 2016·Human Vaccines & Immunotherapeutics·Mohammed DanyDirk Elston
Mar 26, 2016·PloS One·Francesco PappalardoMassimo Libra
May 18, 2017·Pigment Cell & Melanoma Research·Karine Flem-KarlsenCaroline E Nunes-Xavier
Nov 12, 2017·BMC Cancer·Priscila Daniele Ramos CiriloLuiz Otavio Ferraz Penalva
Jul 12, 2018·Current Opinion in Oncology·Giovanni FucàMassimo Di Nicola
Apr 19, 2017·Oncotarget·Eva HulstaertPieter Mestdagh
Jan 7, 2017·European Surgery : ACA : Acta Chirurgica Austriaca·G JomrichL Müllauer
May 26, 2018·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A BoadaJ Malvehy
Nov 30, 2016·Frontiers in Oncology·Seyma DemirsoyPatrizia Agostinis
Jul 17, 2020·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ryan J SullivanPaolo A Ascierto
Feb 12, 2020·ACS Chemical Biology·Tim P HogervorstJeroen D C Codée

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Clinical Trials Mentioned

NCT01721772
NCT01721746
NCT01928394
NCT02017717

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

Expert Opinion on Investigational Drugs
Marlana OrloffTakami Sato
Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Darren M PalathinkalJeremy S Bordeaux
© 2022 Meta ULC. All rights reserved