PMID: 11911978Mar 26, 2002Paper

Novel effect of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells

Neuroscience Letters
Chi Kwan Tsang, Yuto Kamei

Abstract

The nerve growth factor (NGF)-potentiating effect of K vitamins on PC12D cells was investigated. Treatment of PC12D cells with vitamin K(1) or K(2) in the presence of NGF significantly enhanced the proportion of neurite-bearing cells and acetylcholinesterase activity compared with NGF treatment alone. The K vitamins-enhanced neurite outgrowth on PC12D cells was completely blocked by a protein kinase A (PKA) inhibitor or mitogen-activated protein kinase (MAPK) kinase inhibitor PD98059, whereas a protein kinase C inhibitor chelerythrine chloride did not significantly inhibit the enhancing effect of the K vitamins. These results suggest that the K vitamins enhance neurite outgrowth via the activation of PKA and MAPK-mediated signaling pathways in PC12D cells.

References

Nov 2, 1991·BMJ : British Medical Journal·R von Kries
May 21, 1993·Brain Research. Developmental Brain Research·M NakajimaY Hayashi
Jun 26, 1998·Brain Research. Brain Research Reviews·B Connor, M Dragunow
Jan 29, 2000·The European Journal of Neuroscience·J L DupontJ de Barry

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Citations

Sep 15, 2011·Lipids in Health and Disease·Asagi ItoMichio Komai
Apr 21, 2012·Advances in Nutrition·Guylaine Ferland
May 5, 2005·Nutrition Reviews·Natalia A Denisova, Sarah L Booth
Nov 10, 2006·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Atsutoshi InaYuto Kamei
Jan 28, 2004·Nutritional Neuroscience·Isabelle CarriéMartin S Obin
Jul 9, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Motoyuki OtsukaMasao Omata
Mar 16, 2012·BioFactors·Guylaine Ferland
Jul 25, 2021·International Journal of Molecular Sciences·Marwa El SouryGiulia Ronchi

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