Novel environment influences the effect of paradoxical sleep deprivation upon brain and peripheral cytokine gene expression

Neuroscience Letters
Noah T AshleyJennifer E Dumaine

Abstract

Sleep loss increases inflammatory mediators in brain and peripheral tissues, but the mechanisms underlying this association are not fully understood. Male C57BL/6j mice were exposed to paradoxical sleep deprivation (PSD) for 24h using the modified multiple platform (MMP) technique (platforms over water) or two different controls: home cage or a dry platform cage, which constituted a novel environment. PSD mice exhibited increased IL-1β and TNF-α pro-inflammatory gene expression in brain (hypothalamus, hippocampus, pre-frontal cortex), as well as in peripheral tissues (liver, spleen), when compared with home-cage controls. In addition, among PSD mice, TGFβ1, an anti-inflammatory cytokine, was increased in pre-frontal cortex, liver, and spleen in conjunction with elevated serum corticosterone concentration relative to home-cage controls. However, these differences were nearly abolished when PSD mice were compared with control mice subjected to a dry MMP cage, suggesting that simply exposing mice to a novel environment can induce an acute inflammatory response.

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Citations

Jan 25, 2017·Scientific Reports·Jeremy C BornigerA Courtney DeVries
Mar 29, 2019·Physiological Reviews·Luciana BesedovskyMonika Haack
Oct 28, 2019·Frontiers in Endocrinology·Mario G OyolaT John Wu
Dec 20, 2019·Animal Cells and Systems·Lakkyong HwangJae-Woo Yi
Mar 5, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Ila MishraNoah T Ashley
Jan 1, 2020·Stress : the International Journal on the Biology of Stress·Katelyn N BubanT John Wu
Nov 21, 2017·Sleep Medicine Reviews·Matthew D RockstromJames M Krueger

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