Novel equations better predict lung age: a retrospective analysis using two cohorts of participants with medical check-up examinations in Japan

NPJ Primary Care Respiratory Medicine
Yasushi IshidaKatsunori Masuda

Abstract

The lung age equations developed by the Japanese Respiratory Society encounter several problems when being applied in a clinical setting. To establish novel spirometry-derived lung age (SDL age) equations using data from a large number of Japanese healthy never-smokers with normal spirometric measurements and normal body mass indices (BMIs). The participants had undergone medical check-ups at the Center for Preventive Medicine of St Luke's International Hospital between 2004 and 2012. A total of 15,238 Japanese participants (5,499 males and 9,739 females) were chosen for the discovery cohort. The other independent 2,079 individuals were selected for the validation cohort. The original method of Morris and Temple was applied to the discovery cohort. As a result of the linear regression analysis for forced expiratory volume in 1 s (FEV1), spirometric variables using forced vital capacity (FVC) improved the adjusted R(2) values to greater than 0.8. On the basis of the scatter plots between chronological age and SDL age, the best model included the equations using FEV1 and %FVC in females and males (R(2)=0.66 and 0.55, respectively), which was confirmed by the validation cohort. The following equations were developed: SDL age (fema...Continue Reading

References

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Citations

Jul 19, 2019·Interactive Cardiovascular and Thoracic Surgery·Akihiro NagoyaMeinoshin Okumura
Jun 4, 2021·Health & Social Care in the Community·Xiaoguang Zhao, Chenya Du

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