Novel ethosomal gel of clove oil for the treatment of cutaneous candidiasis

Journal of Cosmetic Dermatology
Shweta ShettyR Narayana Charyulu

Abstract

Dual-release mechanism of ethosomal gels (ie, ethosomes and gel) makes them as versatile drug delivery systems for topical applications. Clove oil is obtained from the clove buds exhibited broad antifungal and antibacterial activity. Cutaneous candidiasis is the infection caused by Candida albicans or other Candida species. The aim of the present study was to prepare ethosomal gel of clove oil and evaluate its effectiveness in the treatment of cutaneous candidiasis. Ethosomes of clove oil was formulated by using varying concentrations of soyaphosphotidyl choline and ethanol, and later, it was incorporated into carbapol 974 base gels to form ethosomal gel. The prepared ethosomal gels were also evaluated for spreadability, drug release studies, ex vivo permeation study, and antifungal activity. The optimized formulation did not cause any irritation to the skin since the pH of formulation was in the pH range of skin. The ethosomal gel showed satisfactory antifungal activity against the fungus C. albicans compared to pure clove oil. The results showed that developed formulation could be promising one in the topical delivery of clove oil for the treatment of cutaneous candidiasis.

References

Dec 1, 1972·Antimicrobial Agents and Chemotherapy·M A Burgess, G P Bodey
Feb 9, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·P MuraP Corti
Feb 21, 2003·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Hyun-Ah Cheong, Hoo-Kyun Choi
Mar 12, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·M CarafaE Santucci
Jun 3, 2005·Chemical & Pharmaceutical Bulletin·Mei-Ying NingZhong-Wei Gu
Oct 4, 2005·International Journal of Pharmaceutics·Gamal M M El MaghrabyBarrie C Finnin
Jan 10, 2008·AAPS PharmSciTech·Subheet JainNarendra K Jain
May 16, 2009·European Journal of Dermatology : EJD·Matthias FörsterStephanie Briançon
May 19, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·B MishraSanjay Tiwari
Oct 30, 2009·Journal of Liposome Research·Francesca MaestrelliPaola Mura
Jan 28, 2010·Journal of Liposome Research·Jin-Guang ChenTian-Wen Gao
Oct 3, 2014·Pharmacognosy Research·Rajesh Ramesh HosadurgaR Shashidhara
Apr 7, 2016·International Journal of Pharmaceutical Investigation·Jobin Jose, R Narayana Charyulu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Candida albicans

Candida albicans is an opportunistic, fungal pathogen of humans that frequently causes superficial infections of oral and vaginal mucosal surfaces of debilitated and susceptible individuals. Discover the latest research on Candida albicans here.

Candidiasis

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Candidiasis (ASM)

Candidiasis is a common fungal infection caused by Candida and it can affect many parts for the body including mucosal membranes as well as the gastrointestinal, urinary, and respiratory tracts. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

© 2022 Meta ULC. All rights reserved