Novel expression and regulation of TIMP-1 in Epstein Barr virus-infected cells and its impact on cell survival

Virology
Sue-Jane LinChing-Hwa Tsai

Abstract

Epstein Barr virus (EBV) uses various strategies to manipulate host cytokine production in favor of the survival of infected B-cells. Microarray and cytokine protein array assays revealed that tissue inhibitor of metalloproteinase-1 (TIMP-1) was significantly up-regulated in EBV-infected primary B cells and maintained in abundance in EBV-immortalized lymphoblastoid cell lines (LCLs). TIMP-1 plays critical roles in extracellular matrix homeostasis and regulates signaling pathways. In this study, we demonstrated that the EBV-encoded immediate early lytic protein, Zta, upregulates mainly TIMP-1 expression by binding to the AP-1 site within the TIMP-1 promoter. Moreover, knockdown of TIMP-1 expression promoted cisplastin and cold shock-induced death of LCLs. This study provides a mechanistic link between EBV-induced TIMP-1 expression and its impact on LCL survival.

References

Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
May 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·T YoshizakiJ S Pagano
Dec 3, 1998·The Journal of Clinical Investigation·L GuedezM Stetler-Stevenson
Mar 27, 2002·The Annals of Otology, Rhinology, and Laryngology·Guillermo PlazaCarmen Bellas
Jul 18, 2003·The Journal of General Virology·Alison J Sinclair
Oct 3, 2003·Nature Reviews. Immunology·Ralf Küppers
Mar 10, 2004·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anthony T C ChanRichard F Ambinder
Mar 24, 2004·Critical Reviews in Oncology/hematology·Elise LambertEmmanuelle Petitfrère
May 18, 2004·Cancer Cell·Kwok Wai LoDolly P Huang
Oct 29, 2004·Nature Reviews. Cancer·Lawrence S Young, Alan B Rickinson
Jun 11, 2005·American Journal of Respiratory Cell and Molecular Biology·Kyoung-Hee KimDavid K Madtes
Dec 3, 2005·The Journal of Biological Chemistry·Ayman S El-GuindyGeorge Miller
Jan 13, 2006·Cardiovascular Research·Hideaki NagaseGillian Murphy
Feb 18, 2006·Molecular Cell·Carlo PetosaChristoph W Müller
Mar 24, 2007·Annual Review of Immunology·Andrew D HislopAlan B Rickinson
May 24, 2007·International Journal of Cancer. Journal International Du Cancer·Richard J JonesShannon C Kenney
Jul 16, 2008·Molecular Aspects of Medicine·Gillian Murphy, Hideaki Nagase
Sep 3, 2008·Molecular Aspects of Medicine·Dylan R EdwardsCaroline J Pennington
Nov 3, 2009·Leukemia Research·Liliana Guedez, William G Stetler-Stevenson
Apr 28, 2011·Blood·Lara RossiMargaret A Goodell
Aug 24, 2013·Nature Reviews. Immunology·Rama KhokhaAshley Weiss

❮ Previous
Next ❯

Related Concepts

Related Feeds

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Bowen's Disease

Bowen's disease is thought of as an easily-treatable early stage of skin cancer, characterized by red, scaly patches on the skin. Discover the latest research on Bowen's disease here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

Aminoglycosides (ASM)

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Anal Dysplasia

Anal dysplasia is a precancerous condition in which some cells within the anus transform into abnormal cells. Discover the latest research on anal dysplasia here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis