Novel expression and transcriptional regulation of FoxJ1 during oro-facial morphogenesis.

Human Molecular Genetics
Shankar R VenugopalanBrad A Amendt

Abstract

Axenfeld-Rieger syndrome (ARS) patients with PITX2 point mutations exhibit a wide range of clinical features including mild craniofacial dysmorphism and dental anomalies. Identifying new PITX2 targets and transcriptional mechanisms are important to understand the molecular basis of these anomalies. Chromatin immunoprecipitation assays demonstrate PITX2 binding to the FoxJ1 promoter and PITX2C transgenic mouse fibroblasts and PITX2-transfected cells have increased endogenous FoxJ1 expression. FoxJ1 is expressed at embryonic day 14.5 (E14.5) in early tooth germs, then down-regulated from E15.5-E17.5 and re-expressed in the inner enamel epithelium, oral epithelium, tongue epithelium, sub-mandibular salivary gland and hair follicles during E18.5 and neonate day 1. FoxJ1 and Pitx2 exhibit overlapping expression patterns in the dental and oral epithelium. PITX2 activates the FoxJ1 promoter and, Lef-1 and beta-catenin interact with PITX2 to synergistically regulate the FoxJ1 promoter. FoxJ1 physically interacts with the PITX2 homeodomain to synergistically regulate FoxJ1, providing a positive feedback mechanism for FoxJ1 expression. Furthermore, FoxJ1, PITX2, Lef-1 and beta-catenin act in concert to activate the FoxJ1 promoter. The PI...Continue Reading

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Citations

Nov 23, 2012·Biologie aujourd'hui·Julie JerberBénédicte Durand
Apr 21, 2011·The Journal of Biological Chemistry·Shankar R VenugopalanBrad A Amendt
Oct 16, 2009·Molecular Biology of the Cell·Marouan AbouhamedMartin Bähler
Aug 27, 2013·Human Molecular Genetics·Xiao LiBrad A Amendt
Jul 5, 2013·Respiratory Research·Lukas DidonRonald G Crystal
Aug 15, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Annie SimardAimee K Ryan
Aug 10, 2010·Biology of the Cell·Joëlle ThomasBénédicte Durand
Oct 28, 2016·Heart Failure Reviews·Alexander T Mikhailov, Mario Torrado
Aug 16, 2016·Molecular Neurobiology·Panojot BifshaJacques Drouin
Oct 5, 2018·PLoS Genetics·Zhao SunBrad A Amendt
Sep 19, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Adrien B GeorgesReiner A Veitia

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