Novel expression of neuropeptide Y (NPY) mRNA in hypothalamic regions during development: region-specific effects of maternal deprivation on NPY and Agouti-related protein mRNA

Endocrinology
Kevin L GroveM Susan Smith

Abstract

During development there is novel expression of NPY mRNA in the dorsomedial hypothalamic nucleus (DMH) and perifornical region (PFR), in addition to the arcuate nucleus (ARH). Furthermore, NPY mRNA levels peak in all regions on postnatal d 16 (P16) and decrease to adult levels by P30. The purpose of the present study was to determine whether NPY and agouti-related protein (AGRP) mRNA expression in the different hypothalamic regions on P11 and P16 are similarly affected by fasting. An examination of the full rostral to caudal extent of the hypothalamus revealed two additional regions displaying novel NPY mRNA expression, the parvocellular division of the paraventricular nucleus (PVH) and lateral hypothalamus (LH). Maternal deprivation for 36 h, used to bring about a fast, similarly increased (23-29%) NPY and AGRP mRNA expression in the ARH on P11 and P16. In contrast, NPY expression in the DMH and PFR were significantly decreased (19-30% and 48-53%, respectively), whereas NPY mRNA levels in the PVH and LH were not altered by this treatment. The increase in NPY and AGRP mRNA expression in the ARH in response to maternal deprivation suggests that these neuronal populations respond to signals of energy balance. In contrast, NPY exp...Continue Reading

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Citations

Sep 21, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shin J LeeKevin L Grove
Sep 1, 2004·Neuropeptides·Sergueï O FetissovTomas Hökfelt
Nov 3, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Claire B de La SerreSheng Bi
Nov 21, 2007·The Journal of Comparative Neurology·Maria M GlavasKevin L Grove
Jan 6, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sarah J SpencerQuentin J Pittman
Mar 13, 2009·Organogenesis·Beverly Sara MühlhäuslerI Caroline McMillen
Feb 18, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Alireza Jahan-MihanG Harvey Anderson
Sep 18, 2007·Endocrinology·A-S CarloW Meyerhof
Nov 6, 2010·Endocrine Reviews·Floor Remmers, Henriette A Delemarre-van de Waal
Feb 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Amit VarmaSherin U Devaskar
Jul 6, 2011·Frontiers in Neuroendocrinology·Rebecca E MercerWilliam F Colmers

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