Novel fish hypothalamic neuropeptides stimulate the release of gonadotrophins and growth hormone from the pituitary of sockeye salmon

The Journal of Endocrinology
Masafumi AmanoKazuyoshi Tsutsui

Abstract

We recently identified a cDNA encoding three novel fish hypothalamic neuropeptides, having LPXRF-NH(2) from the goldfish brain. In this study, to clarify the physiological functions of these three LPXRFamide peptides (gfLPXRFa-1, -2, and -3), we analysed the localisation and hypophysiotrophic activity of these peptides using sockeye salmon, Oncorhynchus nerka, in which immunoassay systems for several anterior pituitary hormones have been developed. gfLPXRFa-immunoreactive cell bodies were detected in the nucleus posterioris periventricularis of the hypothalamus and immunoreactive fibres were distributed in various brain regions and the pituitary. We also detected gfLPXRFa-immunoreactivity in the pituitary by competitive enzyme-linked immunosorbent assay combined with reversed-phase HPLC. These three gfLPXRFamide peptides stimulated the release of FSH, LH and GH, but did not affect the release of prolactin (PRL) and somatolactin (SL) from cultured pituitary cells. These results suggest that novel fish hypothalamic LPXR-Famide peptides exist in the brain and pituitary of sockeye salmon and stimulate the release of gonadotrophins and GH from the pituitary.

Citations

Oct 17, 2014·The Journal of Endocrinology·M MoussaviH R Habibi
Sep 16, 2014·General and Comparative Endocrinology·Takayoshi Ubuka, Kazuyoshi Tsutsui
Dec 4, 2012·Molecular and Cellular Endocrinology·Xin QiHaoran Lin
Aug 14, 2012·General and Comparative Endocrinology·Hironori AndoAtsuhiko Hattori
Jun 12, 2012·Progress in Neurobiology·Ishwar ParharTakashi Kitahashi
Mar 7, 2012·General and Comparative Endocrinology·Kazuyoshi TsutsuiLance J Kriegsfeld
Jun 25, 2015·The Journal of Comparative Neurology·José A Paullada-SalmerónJosé A Muñoz-Cueto
Oct 28, 2008·General and Comparative Endocrinology·Kazuyoshi Tsutsui, Tomohiro Osugi
Dec 5, 2015·Frontiers in Endocrinology·Kazuyoshi TsutsuiLance J Kriegsfeld
Aug 27, 2010·Journal of Fish Biology·J F LeatherlandS Barkataki
Jul 17, 2010·Annals of the New York Academy of Sciences·Kazuyoshi Tsutsui
Sep 28, 2015·General and Comparative Endocrinology·Takayoshi UbukaKazuyoshi Tsutsui
Dec 17, 2014·Journal of Neuroendocrinology·T OsugiK Tsutsui
Apr 30, 2013·Molecular and Cellular Endocrinology·Yun LiuChristopher H K Cheng
Dec 30, 2014·Frontiers in Endocrinology·Guro Katrine SandvikFinn-Arne Weltzien
Apr 12, 2014·Frontiers in Endocrinology·Md ShahjahanIshwar S Parhar
Sep 2, 2014·Frontiers in Neuroscience·Tomohiro OsugiKazuyoshi Tsutsui
Nov 12, 2014·Frontiers in Endocrinology·Satoshi Ogawa, Ishwar S Parhar
May 21, 2016·Frontiers in Endocrinology·Saumen Kumar Maitra, Kazi Nurul Hasan
Jun 6, 2016·General and Comparative Endocrinology·Wei PengWei Hu
May 14, 2018·Journal of Neuroendocrinology·María P Di YorioPaula G Vissio
Nov 23, 2017·Frontiers in Endocrinology·José A Muñoz-CuetoTakayoshi Ubuka

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