PMID: 9167847May 1, 1997Paper

Novel fluorinated surfactants for perfluorochemical emulsification: biocompatibility assessments of glycosidic and polyol derivatives

Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
C M EdwardsA Cambon

Abstract

A novel series of fluoro-surfactants, derived from glycosides (monosaccharides) or polyols (ureas or carbamates), have been produced for use in respiratory gas-carrying perfluorochemical emulsions. Compounds were synthesised via simple, but highly selective, routes using highly fluorinated isocyanates with amino alcohols, polyethoxylated alcohols and partially protected sugars at anomeric carbon; yields were 88-95%. Resultant compounds were perfluoroalkylated with hydroxylic "head" groups. The biocompatibility of surfactants with human blood in vitro was assessed using a conventional haemolysis test. Compounds showing insignificant haemolysis at up to 10 g l-1 were further evaluated (i) for their effects on neutrophil chemiluminescence, and (ii) in a human platelet aggregation assay. Some fluoro-surfactants inhibited spontaneous platelet aggregation, in blood anti-coagulated with hirudin, at concentrations of 0.01% (w/v), suggesting possible applications as antithrombotic agents.

References

Nov 1, 1992·The Journal of Allergy and Clinical Immunology·C P NielsonM J Connolly
Jan 1, 1995·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·K C LoweS Thomas
Jan 1, 1994·Critical Reviews in Clinical Laboratory Sciences·T F Zuck, J G Riess
Apr 1, 1993·Transfusion Medicine Reviews·G P Biro

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Citations

Feb 17, 2000·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·K C Lowe
Jul 15, 1998·Artificial Cells, Blood Substitutes, and Immobilization Biotechnology·D M EckmannJ B Grotberg
Feb 7, 2015·Carbohydrate Research·Andrew V Razgulin, Sandro Mecozzi
Dec 27, 2003·Anesthesiology·David M Eckmann, Scott L Diamond

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