Novel fluoroprostacyclin analogs with modified cycloalkylenyl chains. Highly potent and orally active anti-anginal agents

Chemical & Pharmaceutical Bulletin
Y MatsumuraK Hosoki

Abstract

Novel fluoroprostacyclin analogs (1a-f) have been synthesized and pharmacologically evaluated. Compounds 1a-c given intravenously or orally showed potent and long-lasting anti-anginal activities in an animal model.

Citations

Jan 21, 2015·Pharmacology & Therapeutics·Michael MurrayTristan Rawling
Jul 23, 2013·Angewandte Chemie·Theresa LiangTobias Ritter
Jun 12, 2008·Chemical Reviews·M Carmen PachecoVéronique Gouverneur

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